increased T cell derived lymphoma incidence_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0

http://metadb.riken.jp/0002024I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor

increased T cell derived lymphoma incidence_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 1, Christopher B Wilson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448688

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>|Tg(Cd4-cre)1Cwi|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased T cell derived lymphoma incidence
  http://purl.obolibrary.org/obo/MP_0002024

文献

http://purl.org/net/cito/citesAsAuthority

• Konstanze. Pechloff, et.al., The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma., The Journal of experimental medicine, 2010, 207
  http://rdf.ncbi.nlm.nih.gov/pubmed/20439541