Konstanze. Pechloff, et.al., The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma., The Journal of experimental medicine, 2010, 207

http://rdf.ncbi.nlm.nih.gov/pubmed/20439541

Konstanze. Pechloff, et.al., The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma., The Journal of experimental medicine, 2010, 207

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4460818

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4460818

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased T cell number_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005018I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• enlarged spleen_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000691I129P2OlaHsdCd19tm1creCgnCd19GtROSA26Sortm1ITKSYKJrldGtROSA26SorCd19tm1creCgnGtROSA26Sortm1ITKSYKJrldCd19GtROSA26Sor
• cachexia_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005150I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• decreased single-positive T cell number_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008083I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• abnormal T cell activation_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001828I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• enlarged spleen_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• increased T cell derived lymphoma incidence_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002024I129P2OlaHsdCd19tm1creCgnCd19GtROSA26Sortm1ITKSYKJrldGtROSA26SorCd19tm1creCgnGtROSA26Sortm1ITKSYKJrldCd19GtROSA26Sor
• increased T cell proliferation_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005348I129P2OlaHsdCd19tm1creCgnCd19GtROSA26Sortm1ITKSYKJrldGtROSA26SorCd19tm1creCgnGtROSA26Sortm1ITKSYKJrldCd19GtROSA26Sor
• hunched posture_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001505I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• premature death_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• abnormal T cell differentiation_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002145I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• increased T cell proliferation_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005348I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• distended abdomen_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001270I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• premature death_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129P2OlaHsdCd19tm1creCgnCd19GtROSA26Sortm1ITKSYKJrldGtROSA26SorCd19tm1creCgnGtROSA26Sortm1ITKSYKJrldCd19GtROSA26Sor
• lethargy_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005202I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• cachexia_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005150I129P2OlaHsdCd19tm1creCgnCd19GtROSA26Sortm1ITKSYKJrldGtROSA26SorCd19tm1creCgnGtROSA26Sortm1ITKSYKJrldCd19GtROSA26Sor
• decreased double-positive T cell number_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005092I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• abnormal T cell activation_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001828I129P2OlaHsdCd19tm1creCgnCd19GtROSA26Sortm1ITKSYKJrldGtROSA26SorCd19tm1creCgnGtROSA26Sortm1ITKSYKJrldCd19GtROSA26Sor
• abnormal spleen morphology_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000689I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor
• increased T cell derived lymphoma incidence_Gt(ROSA)26Sor<tm1(ITK/SYK)Jrld>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002024I129P2OlaHsdC57BL6DBA2GtROSA26Sortm1ITKSYKJrldGtROSA26SorTgCd4cre1Cwi0GtROSA26Sortm1ITKSYKJrldTgCd4cre1CwiGtROSA26Sor