increased leukemia incidence_Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19<tm1(cre)Cgn>/Cd19<+>

http://metadb.riken.jp/0002026I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Is141RdfIs142RdfDel14Trim13Dleu24RdfCd19tm1creCgnCd19Is141RdfCd19Is142RdfDel14Trim13Dleu24RdfCd19tm1creCgn

increased leukemia incidence_Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19<tm1(cre)Cgn>/Cd19<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• CD19 antigen
  http://metadb.riken.jp/db/mgi_rdf/MGI:88319
• insertion, Chr 14, Riccardo Dalla-Favera 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437003
• deletion, Chr 14, Riccardo Dalla-Favera 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437007
• insertion, Chr 14, Riccardo Dalla-Favera 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437004

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19<tm1(cre)Cgn>/Cd19<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Is(14)1Rdf|Cd19<+>|Is(14)2Rdf|Del(14Trim13-Dleu2)4Rdf|Cd19<tm1(cre)Cgn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased leukemia incidence
  http://purl.obolibrary.org/obo/MP_0002026

文献

http://purl.org/net/cito/citesAsAuthority

• Ulf. Klein, et.al., The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia., Cancer cell, 2010, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/20060366