Ulf. Klein, et.al., The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia., Cancer cell, 2010, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/20060366

Ulf. Klein, et.al., The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia., Cancer cell, 2010, 17

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Is(14)1Rdf
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437012
• Is(14)2Rdf
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437013
• Mirc30<tm1.1Rdf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437043
• Mirc30<tm1.2Rdf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437041
• Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437040
• Del(14Trim13-Dleu2)3Rdf
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437015

class

http://purl.org/net/cito/citesAsAuthority

• Is(14)1Rdf
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437012
• Is(14)2Rdf
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437013
• Mirc30<tm1.1Rdf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437043
• Mirc30<tm1.2Rdf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437041
• Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437040
• Del(14Trim13-Dleu2)3Rdf
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437015

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Mirc30<tm1.1Rdf>/Mirc30<tm1.1Rdf>
  http://metadb.riken.jp/0005014I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Cd19tm1creCgnCd19Mirc30tm11RdfMirc30tm11RdfCd19tm1creCgnMirc30tm11RdfCd19
• increased spleen white pulp amount_Cd19<tm1(cre)Cgn>/Cd19<+>,Mirc30<tm1.1Rdf>/Mirc30<tm1.1Rdf>
  http://metadb.riken.jp/0008478I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Cd19tm1creCgnCd19Mirc30tm11RdfMirc30tm11RdfCd19tm1creCgnMirc30tm11RdfCd19
• increased spleen white pulp amount_Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008478I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Is141RdfIs142RdfDel14Trim13Dleu24RdfCd19tm1creCgnCd19Is141RdfCd19Is142RdfDel14Trim13Dleu24RdfCd19tm1creCgn
• increased B cell derived lymphoma incidence_Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002023I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Is141RdfIs142RdfDel14Trim13Dleu24RdfCd19tm1creCgnCd19Is141RdfCd19Is142RdfDel14Trim13Dleu24RdfCd19tm1creCgn
• increased B cell derived lymphoma incidence_Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/0002023I129S1Sv129S4SvJaeSorC57BL6Del14Trim13Dleu24RdfDel14Trim13Dleu24RdfDel14Trim13Dleu24Rdf
• increased leukemia incidence_Mirc30<tm1.2Rdf>/Mirc30<tm1.2Rdf>
  http://metadb.riken.jp/0002026I129S1Sv129S4SvJaeSorC57BL6Mirc30tm12RdfMirc30tm12RdfMirc30tm12Rdf
• decreased survivor rate_Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/0008770I129S1Sv129S4SvJaeSorC57BL6Del14Trim13Dleu24RdfDel14Trim13Dleu24RdfDel14Trim13Dleu24Rdf
• increased B cell derived lymphoma incidence_Cd19<tm1(cre)Cgn>/Cd19<+>,Mirc30<tm1.1Rdf>/Mirc30<tm1.1Rdf>
  http://metadb.riken.jp/0002023I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Cd19tm1creCgnCd19Mirc30tm11RdfMirc30tm11RdfCd19tm1creCgnMirc30tm11RdfCd19
• abnormal B cell proliferation_Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/0005153I129S1Sv129S4SvJaeSorC57BL6Del14Trim13Dleu24RdfDel14Trim13Dleu24RdfDel14Trim13Dleu24Rdf
• abnormal B cell proliferation_Mirc30<tm1.2Rdf>/Mirc30<tm1.2Rdf>
  http://metadb.riken.jp/0005153I129S1Sv129S4SvJaeSorC57BL6Mirc30tm12RdfMirc30tm12RdfMirc30tm12Rdf
• increased B cell number_Mirc30<tm1.2Rdf>/Mirc30<tm1.2Rdf>
  http://metadb.riken.jp/0005014I129S1Sv129S4SvJaeSorC57BL6Mirc30tm12RdfMirc30tm12RdfMirc30tm12Rdf
• increased spleen white pulp amount_Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/0008478I129S1Sv129S4SvJaeSorC57BL6Del14Trim13Dleu24RdfDel14Trim13Dleu24RdfDel14Trim13Dleu24Rdf
• increased leukemia incidence_Cd19<tm1(cre)Cgn>/Cd19<+>,Mirc30<tm1.1Rdf>/Mirc30<tm1.1Rdf>
  http://metadb.riken.jp/0002026I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Cd19tm1creCgnCd19Mirc30tm11RdfMirc30tm11RdfCd19tm1creCgnMirc30tm11RdfCd19
• increased leukemia incidence_Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/0002026I129S1Sv129S4SvJaeSorC57BL6Del14Trim13Dleu24RdfDel14Trim13Dleu24RdfDel14Trim13Dleu24Rdf
• increased B-1a cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Mirc30<tm1.1Rdf>/Mirc30<tm1.1Rdf>
  http://metadb.riken.jp/0008167I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Cd19tm1creCgnCd19Mirc30tm11RdfMirc30tm11RdfCd19tm1creCgnMirc30tm11RdfCd19
• increased leukemia incidence_Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002026I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Is141RdfIs142RdfDel14Trim13Dleu24RdfCd19tm1creCgnCd19Is141RdfCd19Is142RdfDel14Trim13Dleu24RdfCd19tm1creCgn
• premature death_Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJaeSorC57BL6Del14Trim13Dleu24RdfDel14Trim13Dleu24RdfDel14Trim13Dleu24Rdf
• increased B cell derived lymphoma incidence_Del(14Trim13-Dleu2)4Rdf/+
  http://metadb.riken.jp/0002023I129S1Sv129S4SvJaeSorC57BL6Del14Trim13Dleu24RdfDel14Trim13Dleu24Rdf
• increased spleen white pulp amount_Mirc30<tm1.2Rdf>/Mirc30<tm1.2Rdf>
  http://metadb.riken.jp/0008478I129S1Sv129S4SvJaeSorC57BL6Mirc30tm12RdfMirc30tm12RdfMirc30tm12Rdf
• increased B-1a cell number_Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/0008167I129S1Sv129S4SvJaeSorC57BL6Del14Trim13Dleu24RdfDel14Trim13Dleu24RdfDel14Trim13Dleu24Rdf
• increased B-1a cell number_Mirc30<tm1.2Rdf>/Mirc30<tm1.2Rdf>
  http://metadb.riken.jp/0008167I129S1Sv129S4SvJaeSorC57BL6Mirc30tm12RdfMirc30tm12RdfMirc30tm12Rdf
• increased B-1a cell number_Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008167I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Is141RdfIs142RdfDel14Trim13Dleu24RdfCd19tm1creCgnCd19Is141RdfCd19Is142RdfDel14Trim13Dleu24RdfCd19tm1creCgn
• increased B cell derived lymphoma incidence_Mirc30<tm1.2Rdf>/Mirc30<tm1.2Rdf>
  http://metadb.riken.jp/0002023I129S1Sv129S4SvJaeSorC57BL6Mirc30tm12RdfMirc30tm12RdfMirc30tm12Rdf
• increased B cell number_Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005014I129P2OlaHsd129S1Sv129S4SvJaeSorC57BL6Is141RdfIs142RdfDel14Trim13Dleu24RdfCd19tm1creCgnCd19Is141RdfCd19Is142RdfDel14Trim13Dleu24RdfCd19tm1creCgn
• increased B cell number_Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf
  http://metadb.riken.jp/0005014I129S1Sv129S4SvJaeSorC57BL6Del14Trim13Dleu24RdfDel14Trim13Dleu24RdfDel14Trim13Dleu24Rdf