increased leukemia incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0

http://metadb.riken.jp/0002026I129P2OlaHsdC57BL6CBAJFVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0GtROSA26Sortm4CAGhsb5NkiTgTnpbsbGrOncaGsvaGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1Cgn

increased leukemia incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 2, Daniel G Tenen
  http://metadb.riken.jp/db/mgi_rdf/MGI:3621056
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgenic transposon concatemer #a, George S Vassiliou
  http://metadb.riken.jp/db/mgi_rdf/MGI:5004899

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>|TgTn(pb-sb-GrOnc)#aGsva|Gt(ROSA)26Sor<+>|Tg(tetO-BCR/ABL1)2Dgt|Tg(Mx1-cre)1Cgn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA/J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased leukemia incidence
  http://purl.obolibrary.org/obo/MP_0002026

文献

http://purl.org/net/cito/citesAsAuthority

• George. Giotopoulos, et.al., A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression., The Journal of experimental medicine, 2015, 212
  http://rdf.ncbi.nlm.nih.gov/pubmed/26304963