George. Giotopoulos, et.al., A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression., The Journal of experimental medicine, 2015, 212

http://rdf.ncbi.nlm.nih.gov/pubmed/26304963

George. Giotopoulos, et.al., A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression., The Journal of experimental medicine, 2015, 212

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased leukocyte cell number_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0000218I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
• increased leukocyte cell number_Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0000218IC57BL6CBAJDBA2FVBNTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtTgMx1cre1CgnTgtetOBCRABL12Dgt
• increased granulocyte number_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0000322I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
• increased granulocyte number_Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0000322IC57BL6CBAJDBA2FVBNTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtTgMx1cre1CgnTgtetOBCRABL12Dgt
• increased leukemia incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0002026I129P2OlaHsdC57BL6CBAJFVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0GtROSA26Sortm4CAGhsb5NkiTgTnpbsbGrOncaGsvaGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1Cgn
• premature death_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
他11件を見る
• premature death_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CBAJFVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0GtROSA26Sortm4CAGhsb5NkiTgTnpbsbGrOncaGsvaGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1Cgn
• premature death_Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0002083IC57BL6CBAJDBA2FVBNTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtTgMx1cre1CgnTgtetOBCRABL12Dgt
• increased basophil cell number_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0002606I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
• decreased hemoglobin content_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0002874I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
• increased liver weight_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
• increased hematopoietic stem cell number_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0004809I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
• increased spleen weight_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0004952I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
• increased chronic myelocytic leukemia incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0005481I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
• increased chronic myelocytic leukemia incidence_Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0005481IC57BL6CBAJDBA2FVBNTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtTgMx1cre1CgnTgtetOBCRABL12Dgt
• abnormal hematopoietic stem cell physiology_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0010763I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki
• increased myeloid cell number_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
  http://metadb.riken.jp/0013663I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki