increased leukemia incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0002026I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn

increased leukemia incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein tyrosine phosphatase, non-receptor type 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:99511
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptpn11<+>|Ptpn11<tm1Ckq>|Tg(Mx1-cre)1Cgn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased leukemia incidence
  http://purl.obolibrary.org/obo/MP_0002026

文献

http://purl.org/net/cito/citesAsAuthority

• Dan. Xu, et.al., Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells., The Journal of experimental medicine, 2011, 208
  http://rdf.ncbi.nlm.nih.gov/pubmed/21930766