Dan. Xu, et.al., Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells., The Journal of experimental medicine, 2011, 208

http://rdf.ncbi.nlm.nih.gov/pubmed/21930766

Dan. Xu, et.al., Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells., The Journal of experimental medicine, 2011, 208

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1Ckq>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295460

class

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1Ckq>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5295460

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased B cell derived lymphoma incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002023I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• anemia_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased leukemia incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002026I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• arrested B cell differentiation_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001802I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased acute promyelocytic leukemia incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0004049I129P2OlaHsd129S6SvEvTacC57BL6JPtpn11tm1CkqPtpn11Lyz2tm1creIfoLyz2Ptpn11Lyz2tm1creIfoLyz2Ptpn11tm1Ckq
• enlarged liver_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000599I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased acute lymphoblastic leukemia incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0010336I129S6SvEvTacC57BL6JPtpn11tm1CkqPtpn11TgLckcre1Cwi0Ptpn11Ptpn11tm1CkqTgLckcre1Cwi
• increased spleen weight_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004952I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• enlarged spleen_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased lymphoblastic lymphoma incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0009320I129S6SvEvTacC57BL6JPtpn11tm1CkqPtpn11TgLckcre1Cwi0Ptpn11Ptpn11tm1CkqTgLckcre1Cwi
• decreased hematopoietic stem cell number_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004810I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• myeloid hyperplasia_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010373I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased acute promyelocytic leukemia incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004049I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased hematopoietic stem cell number_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004809I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• embryonic lethality during organogenesis, complete penetrance_Hprt<tm1(CAG-cre)Mnn>/Hprt<+>,Ptpn11<tm1Ckq>/Ptpn11<+>
  http://metadb.riken.jp/0011098I129S1Sv129S6SvEvTacC57BL6JHprttm1CAGcreMnnHprtPtpn11tm1CkqPtpn11HprtHprttm1CAGcreMnnPtpn11Ptpn11tm1Ckq
• myeloid hyperplasia_Ptpn11<tm1Ckq>/Ptpn11<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0010373I129P2OlaHsd129S6SvEvTacC57BL6JPtpn11tm1CkqPtpn11Lyz2tm1creIfoLyz2Ptpn11Lyz2tm1creIfoLyz2Ptpn11tm1Ckq
• abnormal bone marrow cell morphology/development_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002398I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased neutrophil cell number_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000219I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased lymphoblastic lymphoma incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0009320I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• premature death_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6JPtpn11tm1CkqPtpn11TgLckcre1Cwi0Ptpn11Ptpn11tm1CkqTgLckcre1Cwi
• extramedullary hematopoiesis_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000240I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased B cell derived lymphoma incidence_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn11<tm1Ckq>/Ptpn11<+>
  http://metadb.riken.jp/0002023I129P2OlaHsd129S6SvEvTacC57BL6JCd19tm1creCgnCd19Ptpn11tm1CkqPtpn11Cd19Ptpn11Cd19tm1creCgnPtpn11tm1Ckq
• aneuploidy_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004024I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• premature death_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• abnormal heart tube morphology_Hprt<tm1(CAG-cre)Mnn>/Hprt<+>,Ptpn11<tm1Ckq>/Ptpn11<+>
  http://metadb.riken.jp/0000270I129S1Sv129S6SvEvTacC57BL6JHprttm1CAGcreMnnHprtPtpn11tm1CkqPtpn11HprtHprttm1CAGcreMnnPtpn11Ptpn11tm1Ckq
• increased acute lymphoblastic leukemia incidence_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010336I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• embryonic growth retardation_Hprt<tm1(CAG-cre)Mnn>/Hprt<+>,Ptpn11<tm1Ckq>/Ptpn11<+>
  http://metadb.riken.jp/0003984I129S1Sv129S6SvEvTacC57BL6JHprttm1CAGcreMnnHprtPtpn11tm1CkqPtpn11HprtHprttm1CAGcreMnnPtpn11Ptpn11tm1Ckq
• increased acute lymphoblastic leukemia incidence_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn11<tm1Ckq>/Ptpn11<+>
  http://metadb.riken.jp/0010336I129P2OlaHsd129S6SvEvTacC57BL6JCd19tm1creCgnCd19Ptpn11tm1CkqPtpn11Cd19Ptpn11Cd19tm1creCgnPtpn11tm1Ckq
• abnormal hematopoietic stem cell physiology_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010763I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• premature death_Ptpn11<tm1Ckq>/Ptpn11<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacC57BL6JPtpn11tm1CkqPtpn11Lyz2tm1creIfoLyz2Ptpn11Lyz2tm1creIfoLyz2Ptpn11tm1Ckq
• abnormal craniofacial development_Hprt<tm1(CAG-cre)Mnn>/Hprt<+>,Ptpn11<tm1Ckq>/Ptpn11<+>
  http://metadb.riken.jp/0003935I129S1Sv129S6SvEvTacC57BL6JHprttm1CAGcreMnnHprtPtpn11tm1CkqPtpn11HprtHprttm1CAGcreMnnPtpn11Ptpn11tm1Ckq
• decreased common myeloid progenitor cell number_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008813I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• increased leukocyte cell number_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• premature death_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn11<tm1Ckq>/Ptpn11<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacC57BL6JCd19tm1creCgnCd19Ptpn11tm1CkqPtpn11Cd19Ptpn11Cd19tm1creCgnPtpn11tm1Ckq
• chromosomal instability_Ptpn11<tm1Ckq>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008866I129S6SvEvTacC57BL6C57BL6JCBAPtpn11tm1CkqPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm1CkqTgMx1cre1Cgn
• no abnormal phenotype detected_Ptpn11<tm1Ckq>/Ptpn11<+>
  http://metadb.riken.jp/0002169I129S6SvEvTacC57BL6JPtpn11tm1CkqPtpn11Ptpn11Ptpn11tm1Ckq