increased leukemia incidence_Lmo2<tm2(cre)Thr>/Lmo2<+>,Kmt2a<tm1Thr>/Kmt2a<+>,Mllt1<tm1Thr>/Mllt1<+>

http://metadb.riken.jp/0002026I129SSvEvLmo2tm2creThrLmo2Kmt2atm1ThrKmt2aMllt1tm1ThrMllt1Kmt2atm1ThrMllt1Lmo2Mllt1tm1ThrLmo2tm2creThrKmt2a

increased leukemia incidence_Lmo2<tm2(cre)Thr>/Lmo2<+>,Kmt2a<tm1Thr>/Kmt2a<+>,Mllt1<tm1Thr>/Mllt1<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• LIM domain only 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:102811
• myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1927238
• lysine (K)-specific methyltransferase 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:96995

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lmo2<tm2(cre)Thr>/Lmo2<+>,Kmt2a<tm1Thr>/Kmt2a<+>,Mllt1<tm1Thr>/Mllt1<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kmt2a<tm1Thr>|Mllt1<+>|Lmo2<+>|Mllt1<tm1Thr>|Lmo2<tm2(cre)Thr>|Kmt2a<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased leukemia incidence
  http://purl.obolibrary.org/obo/MP_0002026

文献

http://purl.org/net/cito/citesAsAuthority

• Alan. Forster, et.al., Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer., Cancer cell, 2003, 3
  http://rdf.ncbi.nlm.nih.gov/pubmed/12781363
• Lesley F. Drynan, et.al., Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis., The EMBO journal, 2005, 24
  http://rdf.ncbi.nlm.nih.gov/pubmed/16096649