increased lung adenocarcinoma incidence_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*L858R)#Hev/0

http://metadb.riken.jp/0002027I129C57BL6CBATgScgb1a1rtTA1Jaw0TgtetOEGFRL858RHev0TgScgb1a1rtTA1JawTgtetOEGFRL858RHev

increased lung adenocarcinoma incidence_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*L858R)#Hev/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion, Harold E Varmus
  http://metadb.riken.jp/db/mgi_rdf/MGI:5449266
• transgene insertion 1, Jeffrey A Whitsett
  http://metadb.riken.jp/db/mgi_rdf/MGI:2652186

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-EGFR*L858R)#Hev/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Scgb1a1-rtTA)1Jaw|Tg(tetO-EGFR*L858R)#Hev

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lung adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0002027

文献

http://purl.org/net/cito/citesAsAuthority

• Lucia. Regales, et.al., Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors., PloS one, 2007, 2
  http://rdf.ncbi.nlm.nih.gov/pubmed/17726540
• Elza C. de Bruin, et.al., Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer., Cancer discovery, 2014, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/24535670