increased carcinoma incidence_Gt(ROSA)26Sor<tm1(CAG-Bmi1,-EGFP)Nki>/Gt(ROSA)26Sor<+>,Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Gfap-cre)2Brn/0

http://metadb.riken.jp/0002038EI129129P2OlaHsdFVBNorI129129P2OlaHsdC57BL6FVBNGtROSA26Sortm1CAGBmi1EGFPNkiGtROSA26SorRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgGfapcre2Brn0Rb1tm2BrnGtROSA26Sortm1CAGBmi1EGFPNkiTrp53tm1BrnTgGfapcre2BrnGtROSA26Sor

increased carcinoma incidence_Gt(ROSA)26Sor<tm1(CAG-Bmi1,-EGFP)Nki>/Gt(ROSA)26Sor<+>,Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Gfap-cre)2Brn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• RB transcriptional corepressor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97874
• transgene insertion 2, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:2671944
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(CAG-Bmi1,-EGFP)Nki>/Gt(ROSA)26Sor<+>,Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Gfap-cre)2Brn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rb1<tm2Brn>|Gt(ROSA)26Sor<tm1(CAG-Bmi1,-EGFP)Nki>|Trp53<tm1Brn>|Tg(Gfap-cre)2Brn|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0002038

文献

http://purl.org/net/cito/citesAsAuthority

• Bart A. Westerman, et.al., GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors., PloS one, 2012, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/22574128