increased carcinoma incidence_Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0,Trp53<tm1Brn>/Trp53<tm1Brn>

http://metadb.riken.jp/0002038I129P2OlaHsdC57BL6DBA2DBA2JFVBNTgKRT14cre8Brn0TgKRT5Akt1Jmpa0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT5Akt1JmpaTgKRT14cre8Brn

increased carcinoma incidence_Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0,Trp53<tm1Brn>/Trp53<tm1Brn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion, Jesus M Paramio
  http://metadb.riken.jp/db/mgi_rdf/MGI:3842825
• transgene insertion 8, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177242

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0,Trp53<tm1Brn>/Trp53<tm1Brn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brn>|Tg(KRT5-Akt1*)Jmpa|Tg(KRT14-cre)8Brn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0002038

文献

http://purl.org/net/cito/citesAsAuthority

• Marta. Moral, et.al., Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma., Cancer research, 2009, 69
  http://rdf.ncbi.nlm.nih.gov/pubmed/19176372