Marta. Moral, et.al., Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma., Cancer research, 2009, 69

http://rdf.ncbi.nlm.nih.gov/pubmed/19176372

Marta. Moral, et.al., Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma., Cancer research, 2009, 69

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal sublingual gland morphology_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0004035IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• premature death_Pten<tm1Mro>/Pten<tm1Mro>,Tg(KRT14-cre)8Brn/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6DBA2DBA2JFVBNPtentm1MroPtentm1MroTgKRT14cre8Brn0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT14cre8BrnPtentm1Mro
• increased keratinocyte proliferation_Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0009583I129P2OlaHsdC57BL6DBA2DBA2JFVBNTgKRT14cre8Brn0TgKRT5Akt1Jmpa0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT5Akt1JmpaTgKRT14cre8Brn
• increased squamous cell carcinoma incidence_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0004207IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• oral erythroplakia_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0013492IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• abnormal palatine gland morphology_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0000615IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• increased carcinoma incidence_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0002038IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• abnormal mucosal lining of the mouth_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0003745IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• increased tumor incidence_Rb1<tm2Brn>/Rb1<tm2Brn>,Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0002020I129C57BL6DBA2DBA2JFVBNRb1tm2BrnRb1tm2BrnTgKRT14cre8Brn0TgKRT5Akt1Jmpa0TgKRT5Akt1JmpaRb1tm2BrnTgKRT14cre8Brn
• increased trichoepithelioma incidence_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0002732IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• increased carcinoma incidence_Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002038I129P2OlaHsdC57BL6DBA2DBA2JFVBNTgKRT14cre8Brn0TgKRT5Akt1Jmpa0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT5Akt1JmpaTgKRT14cre8Brn
• weakness_Pten<tm1Mro>/Pten<tm1Mro>,Tg(KRT14-cre)8Brn/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0000746I129P2OlaHsdC57BL6DBA2DBA2JFVBNPtentm1MroPtentm1MroTgKRT14cre8Brn0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT14cre8BrnPtentm1Mro
• abnormal mucosal lining of the mouth_Rb1<tm2Brn>/Rb1<tm2Brn>,Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0003745I129C57BL6DBA2DBA2JFVBNRb1tm2BrnRb1tm2BrnTgKRT14cre8Brn0TgKRT5Akt1Jmpa0TgKRT5Akt1JmpaRb1tm2BrnTgKRT14cre8Brn
• abnormal tumor morphology_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0003448IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• abnormal tumor morphology_Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0003448I129P2OlaHsdC57BL6DBA2DBA2JFVBNTgKRT14cre8Brn0TgKRT5Akt1Jmpa0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT5Akt1JmpaTgKRT14cre8Brn
• increased carcinoma incidence_Pten<tm1Mro>/Pten<tm1Mro>,Tg(KRT14-cre)8Brn/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002038I129P2OlaHsdC57BL6DBA2DBA2JFVBNPtentm1MroPtentm1MroTgKRT14cre8Brn0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT14cre8BrnPtentm1Mro
• increased cell proliferation_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0000351IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• increased adenocarcinoma incidence_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0009308IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• decreased keratinocyte proliferation_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0009584IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• increased cell proliferation_Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0000351I129P2OlaHsdC57BL6DBA2DBA2JFVBNTgKRT14cre8Brn0TgKRT5Akt1Jmpa0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT5Akt1JmpaTgKRT14cre8Brn
• oral leukoplakia_Tg(KRT5-Akt1*)Jmpa/0
  http://metadb.riken.jp/0003751IC57BL6DBA2DBA2JFVBNTgKRT5Akt1Jmpa0TgKRT5Akt1Jmpa
• increased squamous cell carcinoma incidence_Tg(KRT14-cre)8Brn/0,Tg(KRT5-Akt1*)Jmpa/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0004207I129P2OlaHsdC57BL6DBA2DBA2JFVBNTgKRT14cre8Brn0TgKRT5Akt1Jmpa0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgKRT5Akt1JmpaTgKRT14cre8Brn