increased carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?

http://metadb.riken.jp/0002038I129Sv129P2OlaHsdC57BL6FVBICRKrastm4TyjKrasTrp53tm1BrnTrp53TgKRT5crePGR1DerKrastm4TyjTgKRT5crePGR1DerKrasTrp53tm1BrnTrp53

increased carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Dennis R Roop
  http://metadb.riken.jp/db/mgi_rdf/MGI:2651407
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<tm4Tyj>|Tg(KRT5-cre/PGR)1Der|Kras<+>|Trp53<tm1Brn>|Trp53<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * FVB * ICR

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0002038

文献

http://purl.org/net/cito/citesAsAuthority

• Carlos. Caulin, et.al., An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations., The Journal of clinical investigation, 2007, 117
  http://rdf.ncbi.nlm.nih.gov/pubmed/17607363