Carlos. Caulin, et.al., An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations., The Journal of clinical investigation, 2007, 117

http://rdf.ncbi.nlm.nih.gov/pubmed/17607363

Carlos. Caulin, et.al., An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations., The Journal of clinical investigation, 2007, 117

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm3Glo>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0002038I129Sv129P2OlaHsdC57BL6FVBICRKrastm4TyjKrasTrp53tm1BrnTrp53tm3GloTgKRT5crePGR1DerKrastm4TyjKrasTrp53tm3GloTgKRT5crePGR1DerTrp53tm1Brn
• decreased incidence of tumors by chemical induction_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0004502I129Sv129P2OlaHsdC57BL6FVBICRKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgKRT5crePGR1DerTrp53tm1BrnKrastm4TyjKrasTgKRT5crePGR1Der
• increased incidence of tumors by chemical induction_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm3Glo>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0004499I129Sv129P2OlaHsdC57BL6FVBICRKrastm4TyjKrasTrp53tm1BrnTrp53tm3GloTgKRT5crePGR1DerKrastm4TyjKrasTrp53tm3GloTgKRT5crePGR1DerTrp53tm1Brn
• increased skin papilloma incidence_Kras<tm4Tyj>/Kras<+>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0002051I129SvC57BL6FVBICRKrastm4TyjKrasTgKRT5crePGR1DerKrastm4TyjTgKRT5crePGR1DerKras
• increased incidence of tumors by chemical induction_Kras<tm4Tyj>/Kras<+>,Trp53<tm3Glo>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0004499I129SvC57BL6FVBICRKrastm4TyjKrasTrp53tm3GloTrp53TgKRT5crePGR1DerTrp53Krastm4TyjTgKRT5crePGR1DerTrp53tm3GloKras
• increased carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0002038I129Sv129P2OlaHsdC57BL6FVBICRKrastm4TyjKrasTrp53tm1BrnTrp53TgKRT5crePGR1DerKrastm4TyjTgKRT5crePGR1DerKrasTrp53tm1BrnTrp53
• abnormal tumor morphology_Kras<tm4Tyj>/Kras<+>,Trp53<tm3Glo>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0003448I129SvC57BL6FVBICRKrastm4TyjKrasTrp53tm3GloTrp53TgKRT5crePGR1DerTrp53Krastm4TyjTgKRT5crePGR1DerTrp53tm3GloKras
• increased carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm3Glo>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0002038I129SvC57BL6FVBICRKrastm4TyjKrasTrp53tm3GloTrp53TgKRT5crePGR1DerTrp53Krastm4TyjTgKRT5crePGR1DerTrp53tm3GloKras
• increased squamous cell carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0004207I129Sv129P2OlaHsdC57BL6FVBICRKrastm4TyjKrasTrp53tm1BrnTrp53tm1BrnTgKRT5crePGR1DerTrp53tm1BrnKrastm4TyjKrasTgKRT5crePGR1Der
• increased spindle cell carcinoma incidence_Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm3Glo>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0010367I129Sv129P2OlaHsdC57BL6FVBICRKrastm4TyjKrasTrp53tm1BrnTrp53tm3GloTgKRT5crePGR1DerKrastm4TyjKrasTrp53tm3GloTgKRT5crePGR1DerTrp53tm1Brn
• increased metastatic potential_Kras<tm4Tyj>/Kras<+>,Trp53<tm3Glo>/Trp53<+>,Tg(KRT5-cre/PGR)1Der/?
  http://metadb.riken.jp/0001272I129SvC57BL6FVBICRKrastm4TyjKrasTrp53tm3GloTrp53TgKRT5crePGR1DerTrp53Krastm4TyjTgKRT5crePGR1DerTrp53tm3GloKras