abnormal skin morphology_Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0

http://metadb.riken.jp/0002060I129S7SvEvBrdC57BL6C57BL6NTacSJLTrp53tm1BrdTrp53tm1BrdTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgtetOKLF432831RupTrp53tm1BrdTgKRT14rtTA208Jek

abnormal skin morphology_Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 208, Jeffrey E Kudlow
  http://metadb.riken.jp/db/mgi_rdf/MGI:3717742
• transgene insertion 32831, J Michael Ruppert
  http://metadb.riken.jp/db/mgi_rdf/MGI:3717761

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(tetO-KLF4)32831Rup|Trp53<tm1Brd>|Tg(KRT14-rtTA)208Jek

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NTac * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal skin morphology
  http://purl.obolibrary.org/obo/MP_0002060

文献

http://purl.org/net/cito/citesAsAuthority

• K Wade. Foster, et.al., Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia., Oncogene, 2005, 24
  http://rdf.ncbi.nlm.nih.gov/pubmed/15674344