K Wade. Foster, et.al., Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia., Oncogene, 2005, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/15674344

K Wade. Foster, et.al., Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia., Oncogene, 2005, 24

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-KLF4)32831Rup
  http://metadb.riken.jp/db/mgi_rdf/MGI:3717763
• Tg(MMTV-KLF4)1Rup
  http://metadb.riken.jp/db/mgi_rdf/MGI:3717765
• Tg(KRT14-rtTA)208Jek
  http://metadb.riken.jp/db/mgi_rdf/MGI:3717751

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-KLF4)32831Rup
  http://metadb.riken.jp/db/mgi_rdf/MGI:3717763
• Tg(MMTV-KLF4)1Rup
  http://metadb.riken.jp/db/mgi_rdf/MGI:3717765
• Tg(KRT14-rtTA)208Jek
  http://metadb.riken.jp/db/mgi_rdf/MGI:3717751

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hair follicle degeneration_Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0003413IC57BL6SJLTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgKRT14rtTA208JekTgtetOKLF432831Rup
• premature death_Tg(MMTV-KLF4)1Rup/0,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6NTacFVBNJSJLTgMMTVKLF41Rup0Trp53tm1BrdTrp53Trp53tm1BrdTrp53TgMMTVKLF41Rup
• skin lesions_Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0001212IC57BL6SJLTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgKRT14rtTA208JekTgtetOKLF432831Rup
• abnormal dermal layer morphology_Tg(MMTV-KLF4)1Rup/0
  http://metadb.riken.jp/0001243I129S7SvEvBrdC57BL6NTacFVBNJSJLTgMMTVKLF41Rup0TgMMTVKLF41Rup
• abnormal epidermis stratum basale morphology_Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0001231IC57BL6SJLTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgKRT14rtTA208JekTgtetOKLF432831Rup
• epidermal hyperplasia_Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0001222IC57BL6SJLTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgKRT14rtTA208JekTgtetOKLF432831Rup
• abnormal skin morphology_Tg(MMTV-KLF4)1Rup/0,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002060I129S7SvEvBrdC57BL6NTacFVBNJSJLTgMMTVKLF41Rup0Trp53tm1BrdTrp53Trp53tm1BrdTrp53TgMMTVKLF41Rup
• hyperkeratosis_Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0001242IC57BL6SJLTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgKRT14rtTA208JekTgtetOKLF432831Rup
• abnormal skin morphology_Trp53<tm1Brd>/Trp53<tm1Brd>,Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0002060I129S7SvEvBrdC57BL6C57BL6NTacSJLTrp53tm1BrdTrp53tm1BrdTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgtetOKLF432831RupTrp53tm1BrdTgKRT14rtTA208Jek
• abnormal epidermal layer morphology_Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0001216IC57BL6SJLTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgKRT14rtTA208JekTgtetOKLF432831Rup
• sebaceous gland atrophy_Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0000649IC57BL6SJLTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgKRT14rtTA208JekTgtetOKLF432831Rup
• abnormal skin morphology_Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0002060IC57BL6SJLTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgKRT14rtTA208JekTgtetOKLF432831Rup
• increased sarcoma incidence_Tg(MMTV-KLF4)1Rup/0,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002032I129S7SvEvBrdC57BL6NTacFVBNJSJLTgMMTVKLF41Rup0Trp53tm1BrdTrp53Trp53tm1BrdTrp53TgMMTVKLF41Rup
• skin lesions_Tg(MMTV-KLF4)1Rup/0,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0001212I129S7SvEvBrdC57BL6NTacFVBNJSJLTgMMTVKLF41Rup0Trp53tm1BrdTrp53Trp53tm1BrdTrp53TgMMTVKLF41Rup
• abnormal dermal layer morphology_Tg(MMTV-KLF4)1Rup/0,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0001243I129S7SvEvBrdC57BL6NTacFVBNJSJLTgMMTVKLF41Rup0Trp53tm1BrdTrp53Trp53tm1BrdTrp53TgMMTVKLF41Rup
• abnormal coat appearance_Tg(KRT14-rtTA)208Jek/Y,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0001510IC57BL6SJLTgKRT14rtTA208JekYTgtetOKLF432831Rup0TgKRT14rtTA208JekTgtetOKLF432831Rup
• abnormal skin morphology_Tg(MMTV-KLF4)1Rup/0
  http://metadb.riken.jp/0002060I129S7SvEvBrdC57BL6NTacFVBNJSJLTgMMTVKLF41Rup0TgMMTVKLF41Rup
• abnormal skin morphology_Trp53<tm1Brd>/Trp53<+>,Tg(KRT14-rtTA)208Jek/0,Tg(tetO-KLF4)32831Rup/0
  http://metadb.riken.jp/0002060I129S7SvEvBrdC57BL6C57BL6NTacSJLTrp53tm1BrdTrp53TgKRT14rtTA208Jek0TgtetOKLF432831Rup0Trp53TgKRT14rtTA208JekTrp53tm1BrdTgtetOKLF432831Rup