seizures_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0

http://metadb.riken.jp/0002064I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeTrp53Ptentm1HwuNf1tm1ParPtenTgGFAPcre25MesNf1

seizures_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 25, Albee Messing
  http://metadb.riken.jp/db/mgi_rdf/MGI:2179047
• neurofibromin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97306
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Elee>|Trp53<+>|Pten<tm1Hwu>|Nf1<tm1Par>|Pten<+>|Tg(GFAP-cre)25Mes|Nf1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• seizures
  http://purl.obolibrary.org/obo/MP_0002064

文献

http://purl.org/net/cito/citesAsAuthority

• Chang-Hyuk. Kwon, et.al., Pten haploinsufficiency accelerates formation of high-grade astrocytomas., Cancer research, 2008, 68
  http://rdf.ncbi.nlm.nih.gov/pubmed/18451155