Chang-Hyuk. Kwon, et.al., Pten haploinsufficiency accelerates formation of high-grade astrocytomas., Cancer research, 2008, 68

http://rdf.ncbi.nlm.nih.gov/pubmed/18451155

Chang-Hyuk. Kwon, et.al., Pten haploinsufficiency accelerates formation of high-grade astrocytomas., Cancer research, 2008, 68

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0002083I129S1Sv129S2SvPas129X1SvJFVBNNf1tm1ParNf1Trp53tm1TyjTrp53TgGFAPcre25Mes0TgGFAPcre25MesTrp53tm1TyjNf1tm1ParTrp53Nf1
• increased startle reflex_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0001488I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeTrp53Ptentm1HwuNf1tm1ParPtenTgGFAPcre25MesNf1
• increased brain tumor incidence_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0009277I129S1Sv129S2SvPas129X1SvJFVBNNf1tm1ParNf1Trp53tm1TyjTrp53TgGFAPcre25Mes0TgGFAPcre25MesTrp53tm1TyjNf1tm1ParTrp53Nf1
• seizures_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0002064I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Trp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeNf1TgGFAPcre25MesNf1tm1ParTrp53
• ataxia_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0001393I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Trp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeNf1TgGFAPcre25MesNf1tm1ParTrp53
• increased startle reflex_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0001488I129S1Sv129S2SvPas129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1TyjTrp53TgGFAPcre25Mes0PtenTgGFAPcre25MesTrp53Trp53tm1TyjPtentm1HwuNf1tm1ParNf1
• increased astrocytoma incidence_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0010277I129S1Sv129S2SvPas129X1SvJFVBNNf1tm1ParNf1Trp53tm1TyjTrp53TgGFAPcre25Mes0TgGFAPcre25MesTrp53tm1TyjNf1tm1ParTrp53Nf1
• unidirectional circling_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0001396I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Trp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeNf1TgGFAPcre25MesNf1tm1ParTrp53
• premature death_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Trp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeNf1TgGFAPcre25MesNf1tm1ParTrp53
• unidirectional circling_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0001396I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeTrp53Ptentm1HwuNf1tm1ParPtenTgGFAPcre25MesNf1
• increased startle reflex_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0001488I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Trp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeNf1TgGFAPcre25MesNf1tm1ParTrp53
• increased astrocytoma incidence_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0010277I129S1Sv129S2SvPas129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1TyjTrp53TgGFAPcre25Mes0PtenTgGFAPcre25MesTrp53Trp53tm1TyjPtentm1HwuNf1tm1ParNf1
• increased brain tumor incidence_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0009277I129S1Sv129S2SvPas129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1TyjTrp53TgGFAPcre25Mes0PtenTgGFAPcre25MesTrp53Trp53tm1TyjPtentm1HwuNf1tm1ParNf1
• increased astrocytoma incidence_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0010277I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeTrp53Ptentm1HwuNf1tm1ParPtenTgGFAPcre25MesNf1
• ataxia_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0001393I129S1Sv129S2SvPas129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1TyjTrp53TgGFAPcre25Mes0PtenTgGFAPcre25MesTrp53Trp53tm1TyjPtentm1HwuNf1tm1ParNf1
• seizures_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0002064I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeTrp53Ptentm1HwuNf1tm1ParPtenTgGFAPcre25MesNf1
• premature death_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0002083I129S1Sv129S2SvPas129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1TyjTrp53TgGFAPcre25Mes0PtenTgGFAPcre25MesTrp53Trp53tm1TyjPtentm1HwuNf1tm1ParNf1
• increased brain tumor incidence_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0009277I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeTrp53Ptentm1HwuNf1tm1ParPtenTgGFAPcre25MesNf1
• ataxia_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0001393I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeTrp53Ptentm1HwuNf1tm1ParPtenTgGFAPcre25MesNf1
• unidirectional circling_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0001396I129S1Sv129S2SvPas129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1TyjTrp53TgGFAPcre25Mes0PtenTgGFAPcre25MesTrp53Trp53tm1TyjPtentm1HwuNf1tm1ParNf1
• seizures_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0002064I129S1Sv129S2SvPas129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1TyjTrp53TgGFAPcre25Mes0PtenTgGFAPcre25MesTrp53Trp53tm1TyjPtentm1HwuNf1tm1ParNf1
• increased brain tumor incidence_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0009277I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Trp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeNf1TgGFAPcre25MesNf1tm1ParTrp53
• premature death_Nf1<tm1Par>/Nf1<+>,Pten<tm1Hwu>/Pten<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Ptentm1HwuPtenTrp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeTrp53Ptentm1HwuNf1tm1ParPtenTgGFAPcre25MesNf1
• increased astrocytoma incidence_Nf1<tm1Par>/Nf1<+>,Trp53<tm1Elee>/Trp53<+>,Tg(GFAP-cre)25Mes/0
  http://metadb.riken.jp/0010277I129S1Sv129S4SvJae129X1SvJFVBNNf1tm1ParNf1Trp53tm1EleeTrp53TgGFAPcre25Mes0Trp53tm1EleeNf1TgGFAPcre25MesNf1tm1ParTrp53