abnormal glucose homeostasis_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0

http://metadb.riken.jp/0002078I129S6SvEvTacC57BL6C57BL6JCBAJFoxo1tm1RdpFoxo1tm1RdpFoxo3tm1RdpFoxo3tm1RdpFoxo4tm1RdpFoxo4tm1RdpTgIns2cre23Herr0Foxo4tm1RdpTgIns2cre23HerrFoxo3tm1RdpFoxo1tm1Rdp

abnormal glucose homeostasis_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• forkhead box O4
  http://metadb.riken.jp/db/mgi_rdf/MGI:1891915
• forkhead box O1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1890077
• transgene insertion 23, Pedro Luis Herrera
  http://metadb.riken.jp/db/mgi_rdf/MGI:4431238
• forkhead box O3
  http://metadb.riken.jp/db/mgi_rdf/MGI:1890081

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Foxo4<tm1Rdp>|Tg(Ins2-cre)23Herr|Foxo3<tm1Rdp>|Foxo1<tm1Rdp>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal glucose homeostasis
  http://purl.obolibrary.org/obo/MP_0002078

文献

http://purl.org/net/cito/citesAsAuthority

• Ja Young. Kim-Muller, et.al., Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice., Cell metabolism, 2014, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/25264246