Ja Young. Kim-Muller, et.al., Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice., Cell metabolism, 2014, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/25264246

Ja Young. Kim-Muller, et.al., Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice., Cell metabolism, 2014, 20

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pancreatic beta cell differentiation_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009175I129S6SvEvTacC57BL6C57BL6JCBAJFoxo1tm1RdpFoxo1tm1RdpFoxo3tm1RdpFoxo3tm1RdpFoxo4tm1RdpFoxo4tm1RdpTgIns2cre23Herr0Foxo4tm1RdpTgIns2cre23HerrFoxo3tm1RdpFoxo1tm1Rdp
• abnormal mitochondrial physiology_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0006036I129S6SvEvTacC57BL6C57BL6JCBAJFoxo1tm1RdpFoxo1tm1RdpFoxo3tm1RdpFoxo3tm1RdpFoxo4tm1RdpFoxo4tm1RdpTgIns2cre23Herr0Foxo4tm1RdpTgIns2cre23HerrFoxo3tm1RdpFoxo1tm1Rdp
• decreased circulating insulin level_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002727I129S6SvEvTacC57BL6C57BL6JCBAJFoxo1tm1RdpFoxo1tm1RdpFoxo3tm1RdpFoxo3tm1RdpFoxo4tm1RdpFoxo4tm1RdpTgIns2cre23Herr0Foxo4tm1RdpTgIns2cre23HerrFoxo3tm1RdpFoxo1tm1Rdp
• decreased insulin secretion_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003059I129S6SvEvTacC57BL6C57BL6JCBAJFoxo1tm1RdpFoxo1tm1RdpFoxo3tm1RdpFoxo3tm1RdpFoxo4tm1RdpFoxo4tm1RdpTgIns2cre23Herr0Foxo4tm1RdpTgIns2cre23HerrFoxo3tm1RdpFoxo1tm1Rdp
• impaired glucose tolerance_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005293I129S6SvEvTacC57BL6C57BL6JCBAJFoxo1tm1RdpFoxo1tm1RdpFoxo3tm1RdpFoxo3tm1RdpFoxo4tm1RdpFoxo4tm1RdpTgIns2cre23Herr0Foxo4tm1RdpTgIns2cre23HerrFoxo3tm1RdpFoxo1tm1Rdp
• hyperglycemia_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0001559I129S6SvEvTacC57BL6C57BL6JCBAJFoxo1tm1RdpFoxo1tm1RdpFoxo3tm1RdpFoxo3tm1RdpFoxo4tm1RdpFoxo4tm1RdpTgIns2cre23Herr0Foxo4tm1RdpTgIns2cre23HerrFoxo3tm1RdpFoxo1tm1Rdp
• abnormal pancreatic beta cell physiology_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003562I129S6SvEvTacC57BL6C57BL6JCBAJFoxo1tm1RdpFoxo1tm1RdpFoxo3tm1RdpFoxo3tm1RdpFoxo4tm1RdpFoxo4tm1RdpTgIns2cre23Herr0Foxo4tm1RdpTgIns2cre23HerrFoxo3tm1RdpFoxo1tm1Rdp
• abnormal glucose homeostasis_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1Rdp>,Foxo4<tm1Rdp>/Foxo4<tm1Rdp>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002078I129S6SvEvTacC57BL6C57BL6JCBAJFoxo1tm1RdpFoxo1tm1RdpFoxo3tm1RdpFoxo3tm1RdpFoxo4tm1RdpFoxo4tm1RdpTgIns2cre23Herr0Foxo4tm1RdpTgIns2cre23HerrFoxo3tm1RdpFoxo1tm1Rdp