premature death_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<+>,Tg(Col1a1-cre)1Kry/0,Trp53<tm1Brn>/Trp53<tm1Brn>

http://metadb.riken.jp/0002083I129129P2OlaHsd129S1Sv129X1SvJFVBNPrkar1atm12LskPrkar1aRb1tm2BrnRb1TgCol1a1cre1Kry0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1KryPrkar1aRb1tm2BrnPrkar1atm12LskRb1

premature death_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<+>,Tg(Col1a1-cre)1Kry/0,Trp53<tm1Brn>/Trp53<tm1Brn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein kinase, cAMP dependent regulatory, type I, alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:104878
• transgene insertion 1, Gerard Karsenty
  http://metadb.riken.jp/db/mgi_rdf/MGI:3041865
• RB transcriptional corepressor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97874
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<+>,Tg(Col1a1-cre)1Kry/0,Trp53<tm1Brn>/Trp53<tm1Brn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brn>|Tg(Col1a1-cre)1Kry|Prkar1a<+>|Rb1<tm2Brn>|Prkar1a<tm1.2Lsk>|Rb1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• premature death
  http://purl.obolibrary.org/obo/MP_0002083

文献

http://purl.org/net/cito/citesAsAuthority

• Yan. Chen, et.al., RANKL blockade prevents and treats aggressive osteosarcomas., Science translational medicine, 2015, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/26659571