premature death_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Npm1<tm1Gsva>/Npm1<+>,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CBAGtROSA26Sortm4CAGhsb5NkiGtROSA26SorNpm1tm1GsvaNpm1TgTnpbsbGrOncaGsva0TgMx1cre1Cgn0GtROSA26Sortm4CAGhsb5NkiNpm1TgMx1cre1CgnGtROSA26SorNpm1tm1GsvaTgTnpbsbGrOncaGsva

premature death_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Npm1<tm1Gsva>/Npm1<+>,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• nucleophosmin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:106184
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgenic transposon concatemer #a, George S Vassiliou
  http://metadb.riken.jp/db/mgi_rdf/MGI:5004899

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Npm1<tm1Gsva>/Npm1<+>,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>|Npm1<+>|Tg(Mx1-cre)1Cgn|Gt(ROSA)26Sor<+>|Npm1<tm1Gsva>|TgTn(pb-sb-GrOnc)#aGsva

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• premature death
  http://purl.obolibrary.org/obo/MP_0002083

文献

http://purl.org/net/cito/citesAsAuthority

• George S. Vassiliou, et.al., Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice., Nature genetics, 2011, 43
  http://rdf.ncbi.nlm.nih.gov/pubmed/21441929