George S. Vassiliou, et.al., Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice., Nature genetics, 2011, 43

http://rdf.ncbi.nlm.nih.gov/pubmed/21441929

George S. Vassiliou, et.al., Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice., Nature genetics, 2011, 43

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• TgTn(pb-sb-GrOnc)#aGsva
  http://metadb.riken.jp/db/mgi_rdf/MGI:5004883
• Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4410291
• Npm1<tm1Gsva>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5004857
• Dppa3<tm1(cre)Peli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5004882

class

http://purl.org/net/cito/citesAsAuthority

• TgTn(pb-sb-GrOnc)#aGsva
  http://metadb.riken.jp/db/mgi_rdf/MGI:5004883
• Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4410291
• Npm1<tm1Gsva>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5004857
• Dppa3<tm1(cre)Peli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5004882

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased B cell derived lymphoma incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Npm1<tm1Gsva>/Npm1<+>,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002023I129P2OlaHsdC57BL6CBAGtROSA26Sortm4CAGhsb5NkiGtROSA26SorNpm1tm1GsvaNpm1TgTnpbsbGrOncaGsva0TgMx1cre1Cgn0GtROSA26Sortm4CAGhsb5NkiNpm1TgMx1cre1CgnGtROSA26SorNpm1tm1GsvaTgTnpbsbGrOncaGsva
• increased spleen weight_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004952IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• embryonic lethality, complete penetrance_Npm1<tm1Gsva>/Npm1<tm1Gsva>,Dppa3<tm1(cre)Peli>/Dppa3<+>
  http://metadb.riken.jp/0011092I129S5SvEvBrd129S7SvEvBrdNpm1tm1GsvaNpm1tm1GsvaDppa3tm1crePeliDppa3Dppa3tm1crePeliNpm1tm1GsvaDppa3
• abnormal common myeloid progenitor cell morphology_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0006410IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• increased leukemia incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Npm1<tm1Gsva>/Npm1<+>,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002026I129P2OlaHsdC57BL6CBAGtROSA26Sortm4CAGhsb5NkiGtROSA26SorNpm1tm1GsvaNpm1TgTnpbsbGrOncaGsva0TgMx1cre1Cgn0GtROSA26Sortm4CAGhsb5NkiNpm1TgMx1cre1CgnGtROSA26SorNpm1tm1GsvaTgTnpbsbGrOncaGsva
• increased granulocyte number_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000322IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• enlarged spleen_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• enlarged liver_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000599IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• premature death_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Npm1<tm1Gsva>/Npm1<+>,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CBAGtROSA26Sortm4CAGhsb5NkiGtROSA26SorNpm1tm1GsvaNpm1TgTnpbsbGrOncaGsva0TgMx1cre1Cgn0GtROSA26Sortm4CAGhsb5NkiNpm1TgMx1cre1CgnGtROSA26SorNpm1tm1GsvaTgTnpbsbGrOncaGsva
• increased leukocyte cell number_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• decreased B cell number_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005017IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• increased hemangiosarcoma incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Npm1<tm1Gsva>/Npm1<+>,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003667I129P2OlaHsdC57BL6CBAGtROSA26Sortm4CAGhsb5NkiGtROSA26SorNpm1tm1GsvaNpm1TgTnpbsbGrOncaGsva0TgMx1cre1Cgn0GtROSA26Sortm4CAGhsb5NkiNpm1TgMx1cre1CgnGtROSA26SorNpm1tm1GsvaTgTnpbsbGrOncaGsva
• increased acute promyelocytic leukemia incidence_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004049IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• increased acute promyelocytic leukemia incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Npm1<tm1Gsva>/Npm1<+>,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004049I129P2OlaHsdC57BL6CBAGtROSA26Sortm4CAGhsb5NkiGtROSA26SorNpm1tm1GsvaNpm1TgTnpbsbGrOncaGsva0TgMx1cre1Cgn0GtROSA26Sortm4CAGhsb5NkiNpm1TgMx1cre1CgnGtROSA26SorNpm1tm1GsvaTgTnpbsbGrOncaGsva
• increased mean platelet volume_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002599IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• increased mean corpuscular volume_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002590IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• increased liver weight_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002981IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• increased B cell derived lymphoma incidence_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002023IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• premature death_Npm1<tm1Gsva>/Npm1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083IC57BL6CBANpm1tm1GsvaNpm1TgMx1cre1Cgn0TgMx1cre1CgnNpm1Npm1tm1Gsva
• increased lymphoma incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Npm1<tm1Gsva>/Npm1<+>,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0012431I129P2OlaHsdC57BL6CBAGtROSA26Sortm4CAGhsb5NkiGtROSA26SorNpm1tm1GsvaNpm1TgTnpbsbGrOncaGsva0TgMx1cre1Cgn0GtROSA26Sortm4CAGhsb5NkiNpm1TgMx1cre1CgnGtROSA26SorNpm1tm1GsvaTgTnpbsbGrOncaGsva