premature death_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0

http://metadb.riken.jp/0002083I129S4SvJaeC57BL6NMRICol1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgCMVrtTA4Bjd0GtROSA26SorCol1a1tm8tetOGFPRNAiRpa3SloweCol1a1TgCMVrtTA4BjdGtROSA26Sortm1rtTAM2Jae

premature death_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 4, Hermann Bujard
  http://metadb.riken.jp/db/mgi_rdf/MGI:3056892
• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>|Col1a1<+>|Tg(CMV-rtTA)4Bjd|Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * NMRI

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• premature death
  http://purl.obolibrary.org/obo/MP_0002083

文献

http://purl.org/net/cito/citesAsAuthority

• Katherine. McJunkin, et.al., Reversible suppression of an essential gene in adult mice using transgenic RNA interference., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21482754