Katherine. McJunkin, et.al., Reversible suppression of an essential gene in adult mice using transgenic RNA interference., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

http://rdf.ncbi.nlm.nih.gov/pubmed/21482754

Katherine. McJunkin, et.al., Reversible suppression of an essential gene in adult mice using transgenic RNA interference., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4999898
• Col1a1<tm9(tetO-GFP/RNAi:Rpa3)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4999901
• Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4999905
• Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4999906

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4999898
• Col1a1<tm9(tetO-GFP/RNAi:Rpa3)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4999901
• Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4999905
• Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4999906

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• weight loss_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0001263I129S4SvJaeC57BL6Col1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm10tetORFPRNAiRpa3Slowe
• weight loss_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0001263I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm11tetORFPRNAiRpa3Slowe
• weight loss_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0001263I129S4SvJaeC57BL6Col1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2Jae
• weight loss_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0001263I129S4SvJaeC57BL6NMRICol1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgCMVrtTA4Bjd0Col1a1TgCMVrtTA4BjdGtROSA26Sortm1rtTAM2JaeCol1a1tm10tetORFPRNAiRpa3SloweGtROSA26Sor
• weight loss_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0001263I129S4SvJaeC57BL6NMRICol1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgCMVrtTA4Bjd0Col1a1GtROSA26Sortm1rtTAM2JaeTgCMVrtTA4BjdCol1a1tm11tetORFPRNAiRpa3SloweGtROSA26Sor
• weight loss_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0001263I129S4SvJaeC57BL6NMRICol1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgCMVrtTA4Bjd0GtROSA26SorCol1a1tm8tetOGFPRNAiRpa3SloweCol1a1TgCMVrtTA4BjdGtROSA26Sortm1rtTAM2Jae
他26件を見る
• weight loss_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0001263I129S4SvJaeC57BL6NMRICol1a1tm8tetOGFPRNAiRpa3SloweCol1a1TgCMVrtTA4Bjd0TgCMVrtTA4BjdCol1a1Col1a1tm8tetOGFPRNAiRpa3Slowe
• infertility_Col1a1<tm9(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001924chimeraI129S4SvJaeC57BL6Col1a1tm9tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1tm9tetOGFPRNAiRpa3SloweGtROSA26Sortm1rtTAM2JaeCol1a1
• premature death_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Col1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm10tetORFPRNAiRpa3Slowe
• premature death_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm11tetORFPRNAiRpa3Slowe
• premature death_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Col1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2Jae
• premature death_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6NMRICol1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgCMVrtTA4Bjd0Col1a1TgCMVrtTA4BjdGtROSA26Sortm1rtTAM2JaeCol1a1tm10tetORFPRNAiRpa3SloweGtROSA26Sor
• premature death_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6NMRICol1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgCMVrtTA4Bjd0Col1a1GtROSA26Sortm1rtTAM2JaeTgCMVrtTA4BjdCol1a1tm11tetORFPRNAiRpa3SloweGtROSA26Sor
• premature death_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6NMRICol1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgCMVrtTA4Bjd0GtROSA26SorCol1a1tm8tetOGFPRNAiRpa3SloweCol1a1TgCMVrtTA4BjdGtROSA26Sortm1rtTAM2Jae
• premature death_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6NMRICol1a1tm8tetOGFPRNAiRpa3SloweCol1a1TgCMVrtTA4Bjd0TgCMVrtTA4BjdCol1a1Col1a1tm8tetOGFPRNAiRpa3Slowe
• no abnormal phenotype detected_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002169I129S4SvJaeC57BL6Col1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm10tetORFPRNAiRpa3SloweGtROSA26Sor
• no abnormal phenotype detected_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002169I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm11tetORFPRNAiRpa3Slowe
• abnormal cell cycle_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003077I129S4SvJaeC57BL6Col1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm10tetORFPRNAiRpa3SloweGtROSA26Sor
• abnormal cell cycle_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003077I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm11tetORFPRNAiRpa3Slowe
• abnormal cell cycle_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0003077I129S4SvJaeC57BL6Col1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2Jae
• abnormal cell cycle_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0003077I129S4SvJaeC57BL6NMRICol1a1tm8tetOGFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgCMVrtTA4Bjd0GtROSA26SorCol1a1tm8tetOGFPRNAiRpa3SloweCol1a1TgCMVrtTA4BjdGtROSA26Sortm1rtTAM2Jae
• abnormal cell cycle_Col1a1<tm8(tetO-GFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Tg(CMV-rtTA)4Bjd/0
  http://metadb.riken.jp/0003077I129S4SvJaeC57BL6NMRICol1a1tm8tetOGFPRNAiRpa3SloweCol1a1TgCMVrtTA4Bjd0TgCMVrtTA4BjdCol1a1Col1a1tm8tetOGFPRNAiRpa3Slowe
• early cellular replicative senescence_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008008I129S4SvJaeC57BL6Col1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm10tetORFPRNAiRpa3SloweGtROSA26Sor
• early cellular replicative senescence_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008008I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm11tetORFPRNAiRpa3Slowe
• decreased erythroid progenitor cell number_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0008973I129S4SvJaeC57BL6Col1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm10tetORFPRNAiRpa3Slowe
• decreased erythroid progenitor cell number_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0008973I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm11tetORFPRNAiRpa3Slowe
• abnormal small intestinal crypt cell physiology_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0010156I129S4SvJaeC57BL6Col1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm10tetORFPRNAiRpa3Slowe
• abnormal small intestinal crypt cell physiology_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0010156I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm11tetORFPRNAiRpa3Slowe
• abnormal small intestinal crypt cell proliferation_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0010157I129S4SvJaeC57BL6Col1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm10tetORFPRNAiRpa3Slowe
• abnormal small intestinal crypt cell proliferation_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>
  http://metadb.riken.jp/0010157I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm11tetORFPRNAiRpa3Slowe
• neonatal lethality, complete penetrance_Col1a1<tm10(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0011087I129S4SvJaeC57BL6Col1a1tm10tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1Col1a1tm10tetORFPRNAiRpa3SloweGtROSA26Sor
• neonatal lethality, complete penetrance_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0011087I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm11tetORFPRNAiRpa3Slowe