increased intestinal adenoma incidence_Rnf43<tm1Cle>/Rnf43<tm1Cle>,Znrf3<tm1Cle>/Znrf3<tm1Cle>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>

http://metadb.riken.jp/0002404I129P2OlaHsdRnf43tm1CleRnf43tm1CleZnrf3tm1CleZnrf3tm1CleLgr5tm1creERT2CleLgr5Lgr5Rnf43tm1CleLgr5tm1creERT2CleZnrf3tm1Cle

increased intestinal adenoma incidence_Rnf43<tm1Cle>/Rnf43<tm1Cle>,Znrf3<tm1Cle>/Znrf3<tm1Cle>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• leucine rich repeat containing G protein coupled receptor 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:1341817
• ring finger protein 43
  http://metadb.riken.jp/db/mgi_rdf/MGI:2442609
• zinc and ring finger 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:3039616

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Rnf43<tm1Cle>/Rnf43<tm1Cle>,Znrf3<tm1Cle>/Znrf3<tm1Cle>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lgr5<+>|Rnf43<tm1Cle>|Lgr5<tm1(cre/ERT2)Cle>|Znrf3<tm1Cle>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased intestinal adenoma incidence
  http://purl.obolibrary.org/obo/MP_0002404

文献

http://purl.org/net/cito/citesAsAuthority

• Bon-Kyoung. Koo, et.al., Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors., Nature, 2012, 488
  http://rdf.ncbi.nlm.nih.gov/pubmed/22895187