abnormal B cell physiology_Igh<tm1Ktom>/Igh<tm1Ktom>,Igk<tm1Ktom>/Igk<tm1Ktom>,Tc(HSA14)SC20Ktom/0,Tc(HSA2)W23Ktom/0

http://metadb.riken.jp/0002459IC57BL6NCrljCBAJNCrljICRIghtm1KtomIghtm1KtomIgktm1KtomIgktm1KtomTcHSA14SC20Ktom0TcHSA2W23Ktom0TcHSA14SC20KtomTcHSA2W23KtomIghtm1KtomIgktm1Ktom

abnormal B cell physiology_Igh<tm1Ktom>/Igh<tm1Ktom>,Igk<tm1Ktom>/Igk<tm1Ktom>,Tc(HSA14)SC20Ktom/0,Tc(HSA2)W23Ktom/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• immunoglobulin heavy chain complex
  http://metadb.riken.jp/db/mgi_rdf/MGI:96442
• transchromosomal, human 2, line W23, Kazuma Tomizuka
  http://metadb.riken.jp/db/mgi_rdf/MGI:5305484
• transchromosomal, human 14, line SC20, Kazuma Tomizuka
  http://metadb.riken.jp/db/mgi_rdf/MGI:5305482
• immunoglobulin kappa chain complex
  http://metadb.riken.jp/db/mgi_rdf/MGI:96494

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Igh<tm1Ktom>/Igh<tm1Ktom>,Igk<tm1Ktom>/Igk<tm1Ktom>,Tc(HSA14)SC20Ktom/0,Tc(HSA2)W23Ktom/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tc(HSA14)SC20Ktom|Tc(HSA2)W23Ktom|Igh<tm1Ktom>|Igk<tm1Ktom>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal B cell physiology
  http://purl.obolibrary.org/obo/MP_0002459

文献

http://purl.org/net/cito/citesAsAuthority

• K. Tomizuka, et.al., Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies., Proceedings of the National Academy of Sciences of the United States of America, 2000, 97
  http://rdf.ncbi.nlm.nih.gov/pubmed/10639146