decreased immunoglobulin level_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?

http://metadb.riken.jp/0002460I129P2OlaHsdBALBcC57BL6FVBBlnktm1PjlnBlnktm1PjlnBtktm1GsvYTgCD19BTKK430RXK24RwheBtktm1GsvTgCD19BTKK430RXK24RwheBlnktm1Pjln

decreased immunoglobulin level_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• B cell linker
  http://metadb.riken.jp/db/mgi_rdf/MGI:96878
• transgene insertion XK24, Rudolf Hendriks
  http://metadb.riken.jp/db/mgi_rdf/MGI:3709261
• Bruton agammaglobulinemia tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:88216

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Btk<tm1Gsv>|Tg(CD19-BTK*K430R)XK24Rwhe|Blnk<tm1Pjln>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased immunoglobulin level
  http://purl.obolibrary.org/obo/MP_0002460

文献

http://purl.org/net/cito/citesAsAuthority

• Sabine. Middendorp, et.al., Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity., Blood, 2005, 105
  http://rdf.ncbi.nlm.nih.gov/pubmed/15331445