Sabine. Middendorp, et.al., Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity., Blood, 2005, 105

http://rdf.ncbi.nlm.nih.gov/pubmed/15331445

Sabine. Middendorp, et.al., Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity., Blood, 2005, 105

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased IgM level_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y
  http://metadb.riken.jp/0001806I129P2OlaHsdBALBcC57BL6Blnktm1PjlnBlnktm1PjlnBtktm1GsvYBtktm1GsvBlnktm1Pjln
• decreased IgG3 level_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y
  http://metadb.riken.jp/0008498I129P2OlaHsdBALBcC57BL6Blnktm1PjlnBlnktm1PjlnBtktm1GsvYBtktm1GsvBlnktm1Pjln
• decreased IgM level_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
  http://metadb.riken.jp/0001806I129P2OlaHsdBALBcC57BL6FVBBlnktm1PjlnBlnktm1PjlnBtktm1GsvYTgCD19BTKK430RXK24RwheBtktm1GsvTgCD19BTKK430RXK24RwheBlnktm1Pjln
• abnormal B cell physiology_Btk<tm1Gsv>/Y
  http://metadb.riken.jp/0002459I129P2OlaHsdC57BL6Btktm1GsvYBtktm1Gsv
• decreased IgG3 level_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
  http://metadb.riken.jp/0008498I129P2OlaHsdBALBcC57BL6FVBBlnktm1PjlnBlnktm1PjlnBtktm1GsvYTgCD19BTKK430RXK24RwheBtktm1GsvTgCD19BTKK430RXK24RwheBlnktm1Pjln
• increased B cell derived lymphoma incidence_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y
  http://metadb.riken.jp/0002023I129P2OlaHsdBALBcC57BL6Blnktm1PjlnBlnktm1PjlnBtktm1GsvYBtktm1GsvBlnktm1Pjln
• abnormal B cell differentiation_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
  http://metadb.riken.jp/0002144I129P2OlaHsdBALBcC57BL6FVBBlnktm1PjlnBlnktm1PjlnBtktm1GsvYTgCD19BTKK430RXK24RwheBtktm1GsvTgCD19BTKK430RXK24RwheBlnktm1Pjln
• decreased immunoglobulin level_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y
  http://metadb.riken.jp/0002460I129P2OlaHsdBALBcC57BL6Blnktm1PjlnBlnktm1PjlnBtktm1GsvYBtktm1GsvBlnktm1Pjln
• decreased immunoglobulin level_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y,Tg(CD19-BTK*K430R)XK24Rwhe/?
  http://metadb.riken.jp/0002460I129P2OlaHsdBALBcC57BL6FVBBlnktm1PjlnBlnktm1PjlnBtktm1GsvYTgCD19BTKK430RXK24RwheBtktm1GsvTgCD19BTKK430RXK24RwheBlnktm1Pjln
• decreased immature B cell number_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y
  http://metadb.riken.jp/0008215I129P2OlaHsdBALBcC57BL6Blnktm1PjlnBlnktm1PjlnBtktm1GsvYBtktm1GsvBlnktm1Pjln
• decreased mature B cell number_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y
  http://metadb.riken.jp/0008211I129P2OlaHsdBALBcC57BL6Blnktm1PjlnBlnktm1PjlnBtktm1GsvYBtktm1GsvBlnktm1Pjln
• abnormal B cell differentiation_Blnk<tm1Pjln>/Blnk<tm1Pjln>,Btk<tm1Gsv>/Y
  http://metadb.riken.jp/0002144I129P2OlaHsdBALBcC57BL6Blnktm1PjlnBlnktm1PjlnBtktm1GsvYBtktm1GsvBlnktm1Pjln