hepatic steatosis_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0

http://metadb.riken.jp/0002628I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn

hepatic steatosis_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 21, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176226
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm1Hwu>|Tg(Alb-cre)21Mgn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * DBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• hepatic steatosis
  http://purl.obolibrary.org/obo/MP_0002628

文献

http://purl.org/net/cito/citesAsAuthority

• Heidi L. Kenerson, et.al., Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation., PloS one, 2011, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/21479224
• Lina. He, et.al., The critical role of AKT2 in hepatic steatosis induced by PTEN loss., The American journal of pathology, 2010, 176
  http://rdf.ncbi.nlm.nih.gov/pubmed/20348245
• Bangyan. Stiles, et.al., Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]., Proceedings of the National Academy of Sciences of the United States of America, 2004, 101
  http://rdf.ncbi.nlm.nih.gov/pubmed/14769918
• Vivian A. Galicia, et.al., Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2., Gastroenterology, 2010, 139
  http://rdf.ncbi.nlm.nih.gov/pubmed/20837017