Vivian A. Galicia, et.al., Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2., Gastroenterology, 2010, 139

http://rdf.ncbi.nlm.nih.gov/pubmed/20837017

Vivian A. Galicia, et.al., Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2., Gastroenterology, 2010, 139

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased hepatocyte proliferation_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003893I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn
• decreased susceptibility to hepatic steatosis_Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002310I129P2OlaHsd129S4SvJaeC57BL6DBAAkt2tm11MbbAkt2tm11MbbPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Akt2tm11MbbPtentm1HwuTgAlbcre21Mgn
• abnormal liver morphology_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000598I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn
• increased liver tumor incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0008019I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn
• increased tumor latency_Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0009828I129P2OlaHsd129S4SvJaeC57BL6DBAAkt2tm11MbbAkt2tm11MbbPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Akt2tm11MbbPtentm1HwuTgAlbcre21Mgn
• abnormal liver morphology_Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000598I129P2OlaHsd129S4SvJaeC57BL6DBAAkt2tm11MbbAkt2tm11MbbPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Akt2tm11MbbPtentm1HwuTgAlbcre21Mgn
• increased cholangiocarcinoma incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0010315I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn
• hepatic steatosis_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002628I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn
• oxidative stress_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003674I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn
• increased circulating alanine transaminase level_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002941I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn
• increased hepatocyte apoptosis_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003887I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn
• increased hepatocellular carcinoma incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003331I129S4SvJaeC57BL6DBAPtentm1HwuPtentm1HwuTgAlbcre21Mgn0Ptentm1HwuTgAlbcre21Mgn

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD06640
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD06640