abnormal keratinocyte differentiation_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>

http://metadb.riken.jp/0002656I129SSvEv129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwRag2tm1FwaRag2tm1FwaTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorRag2tm1FwaGtROSA26SorGtROSA26Sortm1EYFPCosTnfrsf4Pdpk1tm11MlwTnfrsf4tm2creNik

abnormal keratinocyte differentiation_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• tumor necrosis factor receptor superfamily, member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:104512
• 3-phosphoinositide dependent protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1338068
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• recombination activating gene 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97849

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rag2<tm1Fwa>|Gt(ROSA)26Sor<+>|Gt(ROSA)26Sor<tm1(EYFP)Cos>|Tnfrsf4<+>|Pdpk1<tm1.1Mlw>|Tnfrsf4<tm2(cre)Nik>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal keratinocyte differentiation
  http://purl.obolibrary.org/obo/MP_0002656

文献

http://purl.org/net/cito/citesAsAuthority

• Minjun. Yu, et.al., Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease., The Journal of investigative dermatology, 2015, 135
  http://rdf.ncbi.nlm.nih.gov/pubmed/26099023