Minjun. Yu, et.al., Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease., The Journal of investigative dermatology, 2015, 135

http://rdf.ncbi.nlm.nih.gov/pubmed/26099023

Minjun. Yu, et.al., Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease., The Journal of investigative dermatology, 2015, 135

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged lymph nodes_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000702I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• skin fibrosis_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0009932I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• dermatitis_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001194I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• abnormal keratinocyte differentiation_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002656I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• dermatitis_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001194I129SSvEv129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwRag2tm1FwaRag2tm1FwaTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorRag2tm1FwaGtROSA26SorGtROSA26Sortm1EYFPCosTnfrsf4Pdpk1tm11MlwTnfrsf4tm2creNik
• premature death_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• abnormal hypodermis fat layer morphology_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0011156I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• epidermal hyperplasia_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001222I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• abnormal keratinocyte differentiation_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002656I129SSvEv129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwRag2tm1FwaRag2tm1FwaTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorRag2tm1FwaGtROSA26SorGtROSA26Sortm1EYFPCosTnfrsf4Pdpk1tm11MlwTnfrsf4tm2creNik
• impaired skin barrier function_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002796I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• premature hair loss_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005114I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• hyperkeratosis_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001242I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• epidermal hyperplasia_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001222I129SSvEv129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwRag2tm1FwaRag2tm1FwaTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorRag2tm1FwaGtROSA26SorGtROSA26Sortm1EYFPCosTnfrsf4Pdpk1tm11MlwTnfrsf4tm2creNik
• skin lesions_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001212I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• hair follicle degeneration_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003413I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• cachexia_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005150I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• abnormal regulatory T cell number_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004972I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• abnormal T cell physiology_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002444I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• scaly skin_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001192I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• enlarged spleen_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000691I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• premature death_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129SSvEv129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwRag2tm1FwaRag2tm1FwaTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorRag2tm1FwaGtROSA26SorGtROSA26Sortm1EYFPCosTnfrsf4Pdpk1tm11MlwTnfrsf4tm2creNik
• skin hyperplasia_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001214I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor
• thick skin_Pdpk1<tm1.1Mlw>/Pdpk1<tm1.1Mlw>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001200I129X1SvJC57BL6Pdpk1tm11MlwPdpk1tm11MlwTnfrsf4tm2creNikTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26SorTnfrsf4tm2creNikPdpk1tm11MlwTnfrsf4GtROSA26Sortm1EYFPCosGtROSA26Sor