abnormal immune system organ morphology_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0

http://metadb.riken.jp/0002722I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm

abnormal immune system organ morphology_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transforming growth factor, beta receptor II
  http://metadb.riken.jp/db/mgi_rdf/MGI:98729
• transgene insertion 1, Christophe Benoist
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612117
• transgene insertion 1, Christopher B Wilson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448688

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Cd4-cre)1Cwi|Tg(TcraBDC2.5,TcrbBDC2.5)1Doi|Tgfbr2<tm1.2Hlm>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal immune system organ morphology
  http://purl.obolibrary.org/obo/MP_0002722

文献

http://purl.org/net/cito/citesAsAuthority

• Harumichi. Ishigame, et.al., Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/23569233