Harumichi. Ishigame, et.al., Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

http://rdf.ncbi.nlm.nih.gov/pubmed/23569233

Harumichi. Ishigame, et.al., Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tgfb1<tm3.1Flv>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5514235

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal interleukin secretion_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0008568I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• abnormal abdominal lymph node morphology_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0009625I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• abnormal immune system physiology_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0001790I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased susceptibility to autoimmune diabetes_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tnfrsf4<tm2(cre)Nik>/Tnfrsf4<+>,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0004803I129C57BL6NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTnfrsf4tm2creNikTnfrsf4TgTcraBDC25TcrbBDC251Doi0Tgfbr2tm12HlmTgTcraBDC25TcrbBDC251DoiTnfrsf4tm2creNikTnfrsf4
• increased T-helper 1 cell number_Tgfb1<tm3.1Flv>/Tgfb1<tm3.1Flv>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008086I129C57BL6DBA2NODTgfb1tm31FlvTgfb1tm31FlvTgCd4cre1Cwi0Tgfb1tm31FlvTgCd4cre1Cwi
• premature death_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002083I129C57BL6DBA2NODTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgCd4cre1CwiTgfbr2tm12Hlm
• increased inflammatory response_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001846I129C57BL6DBA2NODTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgCd4cre1CwiTgfbr2tm12Hlm
• decreased regulatory T cell number_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0004974I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• abnormal immune serum protein physiology_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0002723I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased regulatory T cell number_Tgfb1<tm3.1Flv>/Tgfb1<tm3.1Flv>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004973I129C57BL6DBA2NODTgfb1tm31FlvTgfb1tm31FlvTgCd4cre1Cwi0Tgfb1tm31FlvTgCd4cre1Cwi
• decreased interleukin-17 secretion_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0008682I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased regulatory T cell number_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0004973I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased interferon-gamma secretion_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0008566I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased regulatory T cell number_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0004973I129S6SvEvTacC57BL6NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgFoxp3EGFPcre1cJbs0TgTcraBDC25TcrbBDC251Doi0TgFoxp3EGFPcre1cJbsTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased regulatory T cell number_Tgfb1<tm3.1Flv>/Tgfb1<tm3.1Flv>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0004973I129C57BL6DBA2NODSJLTgfb1tm31FlvTgfb1tm31FlvTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0Tgfb1tm31FlvTgCd4cre1CwiTgTcraBDC25TcrbBDC251Doi
• decreased interleukin-9 secretion_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0008712I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased T-helper 1 cell number_Tgfb1<tm3.1Flv>/Tgfb1<tm3.1Flv>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0008086I129C57BL6DBA2NODSJLTgfb1tm31FlvTgfb1tm31FlvTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0Tgfb1tm31FlvTgCd4cre1CwiTgTcraBDC25TcrbBDC251Doi
• increased interleukin-21 secretion_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0009057I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased interleukin-2 secretion_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0008687I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased susceptibility to autoimmune diabetes_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0004803I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• abnormal immune system organ morphology_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0002722I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• pancreas inflammation_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0001869I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• increased susceptibility to autoimmune diabetes_Tgfb1<tm3.1Flv>/Tgfb1<tm3.1Flv>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0004803I129C57BL6DBA2NODSJLTgfb1tm31FlvTgfb1tm31FlvTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0Tgfb1tm31FlvTgCd4cre1CwiTgTcraBDC25TcrbBDC251Doi
• abnormal immune system morphology_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0000685I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm
• abnormal spleen morphology_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
  http://metadb.riken.jp/0000689I129C57BL6DBA2NODSJLTgfbr2tm12HlmTgfbr2tm12HlmTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0TgCd4cre1CwiTgTcraBDC25TcrbBDC251DoiTgfbr2tm12Hlm

class

http://purl.org/net/cito/citesAsAuthority

• Tgfb1<tm3.1Flv>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5514235