decreased vertical activity_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>

http://metadb.riken.jp/0002757I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3

decreased vertical activity_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:94862
• mitofusin 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:2442230

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mfn2<tm3Dcc>|Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>|Slc6a3<tm1.1(cre)Bkmn>|Gt(ROSA)26Sor<+>|Slc6a3<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased vertical activity
  http://purl.obolibrary.org/obo/MP_0002757

文献

http://purl.org/net/cito/citesAsAuthority

• Anh H. Pham, et.al., Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit., Human molecular genetics, 2012, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/22859504