Anh H. Pham, et.al., Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit., Human molecular genetics, 2012, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/22859504

Anh H. Pham, et.al., Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit., Human molecular genetics, 2012, 21

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal dopaminergic neuron morphology_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0003243I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• hunched posture_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0001505I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• decreased vertical activity_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0002757I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• kyphosis_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0000160I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• hypoactivity_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0001402I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• abnormal striatum morphology_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0004077I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• neurodegeneration_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0002229I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• premature death_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0002083I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• no abnormal phenotype detected_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn1<tm2Dcc>/Mfn1<tm2Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0002169I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn1tm2DccMfn1tm2DccSlc6a3tm11creBkmnSlc6a3Slc6a3Mfn1tm2DccGtROSA26SorGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmn
• decreased body weight_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0001262I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• abnormal innervation_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0002184I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• loss of dopaminergic neurons_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0003244I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• decreased body size_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0001265I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• bradykinesia_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0005156I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• abnormal mitochondrion morphology_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0006035I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3
• abnormal axonal transport_Gt(ROSA)26Sor<tm1.1(CAG-COX8A/Dendra2)Dcc>/Gt(ROSA)26Sor<+>,Mfn2<tm3Dcc>/Mfn2<tm3Dcc>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>
  http://metadb.riken.jp/0004768I129129S6SvEvTacC57BL6JSJLJGtROSA26Sortm11CAGCOX8ADendra2DccGtROSA26SorMfn2tm3DccMfn2tm3DccSlc6a3tm11creBkmnSlc6a3Mfn2tm3DccGtROSA26Sortm11CAGCOX8ADendra2DccSlc6a3tm11creBkmnGtROSA26SorSlc6a3