abnormal retinal vasculature morphology_Ednrb<tm1.1Nat>/Ednrb<tm1.2Nat>,Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0

http://metadb.riken.jp/0002792I129S1Sv129X1SvJC57BL6Ednrbtm11NatEdnrbtm12NatIgs1tm11CAGBgeoEdn2NatIgs1TgPax6creGFP2Pgr0TgPax6creGFP2PgrIgs1tm11CAGBgeoEdn2NatIgs1Ednrbtm12NatEdnrbtm11Nat

abnormal retinal vasculature morphology_Ednrb<tm1.1Nat>/Ednrb<tm1.2Nat>,Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• intergenic site 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:5319510
• transgene insertion 2, Peter Gruss
  http://metadb.riken.jp/db/mgi_rdf/MGI:3052668
• endothelin receptor type B
  http://metadb.riken.jp/db/mgi_rdf/MGI:102720

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ednrb<tm1.1Nat>/Ednrb<tm1.2Nat>,Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Pax6-cre,GFP)2Pgr|Igs1<tm11(CAG-Bgeo,-Edn2)Nat>|Igs1<+>|Ednrb<tm1.2Nat>|Ednrb<tm1.1Nat>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal retinal vasculature morphology
  http://purl.obolibrary.org/obo/MP_0002792

文献

http://purl.org/net/cito/citesAsAuthority

• Amir. Rattner, et.al., Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/24043815