Amir. Rattner, et.al., Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

http://rdf.ncbi.nlm.nih.gov/pubmed/24043815

Amir. Rattner, et.al., Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Edn2<tm1.2Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5544096
• Ednrb<tm1.2Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5544085
• Igs1<tm11(CAG-Bgeo,-Edn2)Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5544083

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• thin retinal outer nuclear layer_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0008515I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• abnormal retinal vasculature morphology_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pdgfra-cre)1Clc/0
  http://metadb.riken.jp/0002792I129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1TgPdgfracre1Clc0TgPdgfracre1ClcIgs1Igs1tm11CAGBgeoEdn2Nat
• abnormal angiogenesis_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0000260I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• abnormal retinal blood vessel morphology_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0010097I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• thin retinal inner nuclear layer_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0008511I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• postnatal lethality, complete penetrance_Edn2<tm1.2Nat>/Edn2<tm1.2Nat>
  http://metadb.riken.jp/0011085I129S1Sv129X1SvJC57BL6Edn2tm12NatEdn2tm12NatEdn2tm12Nat
• enlarged heart_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000274I129S1Sv129X1SvJC57BL6CBAIgs1tm11CAGBgeoEdn2NatIgs1TgSox2cre1Amc0TgSox2cre1AmcIgs1Igs1tm11CAGBgeoEdn2Nat
• abnormal vascular development_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000259I129S1Sv129X1SvJC57BL6CBAIgs1tm11CAGBgeoEdn2NatIgs1TgSox2cre1Amc0TgSox2cre1AmcIgs1Igs1tm11CAGBgeoEdn2Nat
• abnormal retinal blood vessel pattern_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0010098I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• thin retinal ganglion layer_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0008507I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• abnormal retinal vasculature morphology_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0
  http://metadb.riken.jp/0002792I129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1TgPax6creGFP2Pgr0Igs1Igs1tm11CAGBgeoEdn2NatTgPax6creGFP2Pgr
• abnormal retina morphology_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0
  http://metadb.riken.jp/0001325I129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1TgPax6creGFP2Pgr0Igs1Igs1tm11CAGBgeoEdn2NatTgPax6creGFP2Pgr
• decreased body size_Edn2<tm1.2Nat>/Edn2<tm1.2Nat>
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJC57BL6Edn2tm12NatEdn2tm12NatEdn2tm12Nat
• abnormal retina morphology_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0001325I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• internal hemorrhage_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0001634I129S1Sv129X1SvJC57BL6CBAIgs1tm11CAGBgeoEdn2NatIgs1TgSox2cre1Amc0TgSox2cre1AmcIgs1Igs1tm11CAGBgeoEdn2Nat
• cleft palate_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0000111I129P2OlaHsd129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1Foxg1tm1creSkmFoxg1Foxg1Foxg1tm1creSkmIgs1tm11CAGBgeoEdn2NatIgs1
• postnatal lethality_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0002082I129P2OlaHsd129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1Foxg1tm1creSkmFoxg1Foxg1Foxg1tm1creSkmIgs1tm11CAGBgeoEdn2NatIgs1
• abnormal retinal vasculature morphology_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0002792I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• thin retinal inner nuclear layer_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0
  http://metadb.riken.jp/0008511I129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1TgPax6creGFP2Pgr0Igs1Igs1tm11CAGBgeoEdn2NatTgPax6creGFP2Pgr
• abnormal retinal vasculature morphology_Ednrb<tm1.1Nat>/Ednrb<tm1.2Nat>,Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0
  http://metadb.riken.jp/0002792I129S1Sv129X1SvJC57BL6Ednrbtm11NatEdnrbtm12NatIgs1tm11CAGBgeoEdn2NatIgs1TgPax6creGFP2Pgr0TgPax6creGFP2PgrIgs1tm11CAGBgeoEdn2NatIgs1Ednrbtm12NatEdnrbtm11Nat
• prenatal lethality_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0002080I129S1Sv129X1SvJC57BL6CBAIgs1tm11CAGBgeoEdn2NatIgs1TgSox2cre1Amc0TgSox2cre1AmcIgs1Igs1tm11CAGBgeoEdn2Nat
• retinal detachment_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0003099I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• thin retinal ganglion layer_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0
  http://metadb.riken.jp/0008507I129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1TgPax6creGFP2Pgr0Igs1Igs1tm11CAGBgeoEdn2NatTgPax6creGFP2Pgr
• failure of eyelid fusion_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0009264I129P2OlaHsd129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1Foxg1tm1creSkmFoxg1Foxg1Foxg1tm1creSkmIgs1tm11CAGBgeoEdn2NatIgs1
• open neural tube_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000929I129S1Sv129X1SvJC57BL6CBAIgs1tm11CAGBgeoEdn2NatIgs1TgSox2cre1Amc0TgSox2cre1AmcIgs1Igs1tm11CAGBgeoEdn2Nat
• abnormal dermal pigmentation_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0009385I129S1Sv129X1SvJC57BL6DBA2JIgs1tm11CAGBgeoEdn2NatIgs1TgKRT5cre5132Jlj0Igs1TgKRT5cre5132JljIgs1tm11CAGBgeoEdn2Nat
• retinal fibrosis_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0006186I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• hypoxia_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Six3-cre)69Frty/0
  http://metadb.riken.jp/0005039I129S1Sv129X1SvJC57BL6DBA2Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty0Igs1tm11CAGBgeoEdn2NatIgs1TgSix3cre69Frty
• hypoxia_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0
  http://metadb.riken.jp/0005039I129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1TgPax6creGFP2Pgr0Igs1Igs1tm11CAGBgeoEdn2NatTgPax6creGFP2Pgr
• embryonic growth retardation_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0003984I129S1Sv129X1SvJC57BL6CBAIgs1tm11CAGBgeoEdn2NatIgs1TgSox2cre1Amc0TgSox2cre1AmcIgs1Igs1tm11CAGBgeoEdn2Nat
• thin retinal outer nuclear layer_Igs1<tm11(CAG-Bgeo,-Edn2)Nat>/Igs1<+>,Tg(Pax6-cre,GFP)2Pgr/0
  http://metadb.riken.jp/0008515I129S1Sv129X1SvJC57BL6Igs1tm11CAGBgeoEdn2NatIgs1TgPax6creGFP2Pgr0Igs1Igs1tm11CAGBgeoEdn2NatTgPax6creGFP2Pgr

class

http://purl.org/net/cito/citesAsAuthority

• Edn2<tm1.2Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5544096
• Ednrb<tm1.2Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5544085
• Igs1<tm11(CAG-Bgeo,-Edn2)Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5544083