polycythemia_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Egln3<tm2Fong>/Egln3<tm2Fong>,Tg(CD68-icre)1Bwlx/0

http://metadb.riken.jp/0002872I129S6SvEvTacC57BL6Egln1tm11BreiEgln1tm11BreiEgln3tm2FongEgln3tm2FongTgCD68icre1Bwlx0Egln1tm11BreiTgCD68icre1BwlxEgln3tm2Fong

polycythemia_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Egln3<tm2Fong>/Egln3<tm2Fong>,Tg(CD68-icre)1Bwlx/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• egl-9 family hypoxia-inducible factor 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:1932288
• egl-9 family hypoxia-inducible factor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1932286
• transgene insertion 1, Ben Wielockx
  http://metadb.riken.jp/db/mgi_rdf/MGI:5474941

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Egln3<tm2Fong>/Egln3<tm2Fong>,Tg(CD68-icre)1Bwlx/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Egln1<tm1.1Brei>|Tg(CD68-icre)1Bwlx|Egln3<tm2Fong>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• polycythemia
  http://purl.obolibrary.org/obo/MP_0002872

文献

http://purl.org/net/cito/citesAsAuthority

• Kristin. Franke, et.al., HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis., Blood, 2013, 121
  http://rdf.ncbi.nlm.nih.gov/pubmed/23264599