Kristin. Franke, et.al., HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis., Blood, 2013, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/23264599

Kristin. Franke, et.al., HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis., Blood, 2013, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(CD68-icre)1Bwlx
  http://metadb.riken.jp/db/mgi_rdf/MGI:5474196

class

http://purl.org/net/cito/citesAsAuthority

• Tg(CD68-icre)1Bwlx
  http://metadb.riken.jp/db/mgi_rdf/MGI:5474196

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal megakaryocyte progenitor cell morphology_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0002413IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• abnormal spleen morphology_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0000689IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• hypervolemia_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0010127IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• increased hematocrit_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0002608I129S1Sv129X1SvJC57BL6Egln1tm11BreiEgln1tm11BreiHif1atm3RsjoHif1atm3RsjoTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11BreiHif1atm3Rsjo
• abnormal blood viscosity_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0001598IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• increased spleen weight_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0004952IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• enlarged spleen_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0000691IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• decreased hemoglobin content_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Epas1<tm1Mcs>/Epas1<tm1Mcs>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0002874I129X1SvJC57BL6Egln1tm11BreiEgln1tm11BreiEpas1tm1McsEpas1tm1McsTgCD68icre1Bwlx0Epas1tm1McsTgCD68icre1BwlxEgln1tm11Brei
• increased hematocrit_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0002608IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• domed cranium_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0000440I129S1Sv129X1SvJC57BL6Egln1tm11BreiEgln1tm11BreiHif1atm3RsjoHif1atm3RsjoTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11BreiHif1atm3Rsjo
• reddish skin_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0001190IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• abnormal nucleated erythrocyte cell number_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0012397IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• abnormal lymphocyte cell number_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0000717IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• neonatal lethality_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Egln3<tm2Fong>/Egln3<tm2Fong>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0002058I129S6SvEvTacC57BL6Egln1tm11BreiEgln1tm11BreiEgln3tm2FongEgln3tm2FongTgCD68icre1Bwlx0Egln1tm11BreiTgCD68icre1BwlxEgln3tm2Fong
• thrombocytopenia_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0003179IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• postnatal growth retardation_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0001732IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• decreased hematocrit_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Epas1<tm1Mcs>/Epas1<tm1Mcs>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0000208I129X1SvJC57BL6Egln1tm11BreiEgln1tm11BreiEpas1tm1McsEpas1tm1McsTgCD68icre1Bwlx0Epas1tm1McsTgCD68icre1BwlxEgln1tm11Brei
• postnatal lethality_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0002082I129S1Sv129X1SvJC57BL6Egln1tm11BreiEgln1tm11BreiHif1atm3RsjoHif1atm3RsjoTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11BreiHif1atm3Rsjo
• polycythemia_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Egln3<tm2Fong>/Egln3<tm2Fong>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0002872I129S6SvEvTacC57BL6Egln1tm11BreiEgln1tm11BreiEgln3tm2FongEgln3tm2FongTgCD68icre1Bwlx0Egln1tm11BreiTgCD68icre1BwlxEgln3tm2Fong
• polycythemia_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0002872IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei
• hydroencephaly_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0001891I129S1Sv129X1SvJC57BL6Egln1tm11BreiEgln1tm11BreiHif1atm3RsjoHif1atm3RsjoTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11BreiHif1atm3Rsjo
• increased erythroblast number_Egln1<tm1.1Brei>/Egln1<tm1.1Brei>,Tg(CD68-icre)1Bwlx/0
  http://metadb.riken.jp/0011178IC57BL6Egln1tm11BreiEgln1tm11BreiTgCD68icre1Bwlx0TgCD68icre1BwlxEgln1tm11Brei