decreased susceptibility to pharmacologically induced seizures_Mapt<tm1Hnd>/Mapt<+>,Tg(PDGFB-APPSwInd)20Lms/0

http://metadb.riken.jp/0002887I129X1SvJC57BL6DBA2Mapttm1HndMaptTgPDGFBAPPSwInd20Lms0MaptTgPDGFBAPPSwInd20LmsMapttm1Hnd

decreased susceptibility to pharmacologically induced seizures_Mapt<tm1Hnd>/Mapt<+>,Tg(PDGFB-APPSwInd)20Lms/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• microtubule-associated protein tau
  http://metadb.riken.jp/db/mgi_rdf/MGI:97180
• transgene insertion 20, Lennart Mucke
  http://metadb.riken.jp/db/mgi_rdf/MGI:3057146

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mapt<tm1Hnd>/Mapt<+>,Tg(PDGFB-APPSwInd)20Lms/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mapt<+>|Tg(PDGFB-APPSwInd)20Lms|Mapt<tm1Hnd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129X1/SvJ * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased susceptibility to pharmacologically induced seizures
  http://purl.obolibrary.org/obo/MP_0002887

文献

http://purl.org/net/cito/citesAsAuthority

• Erik D. Roberson, et.al., Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model., Science (New York, N.Y.), 2007, 316
  http://rdf.ncbi.nlm.nih.gov/pubmed/17478722