abnormal excitatory postsynaptic currents_Grin2b<tm1.1Jlbr>/Grin2b<tm1.1Jlbr>,Tg(Camk2a-cre)T29-1Stl/0

http://metadb.riken.jp/0002910I129S6SvEvTacBALBcC57BL6Grin2btm11JlbrGrin2btm11JlbrTgCamk2acreT291Stl0TgCamk2acreT291StlGrin2btm11Jlbr

abnormal excitatory postsynaptic currents_Grin2b<tm1.1Jlbr>/Grin2b<tm1.1Jlbr>,Tg(Camk2a-cre)T29-1Stl/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion T29-1, Susumu Tonegawa
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177646
• glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  http://metadb.riken.jp/db/mgi_rdf/MGI:95821

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Grin2b<tm1.1Jlbr>/Grin2b<tm1.1Jlbr>,Tg(Camk2a-cre)T29-1Stl/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Camk2a-cre)T29-1Stl|Grin2b<tm1.1Jlbr>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * BALB/c * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal excitatory postsynaptic currents
  http://purl.obolibrary.org/obo/MP_0002910

文献

http://purl.org/net/cito/citesAsAuthority

• Jonathan L. Brigman, et.al., Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20357110