increased intestinal adenocarcinoma incidence_Cdh1<tm2Kem>/Cdh1<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Vil-cre)20Syr/0

http://metadb.riken.jp/0002957I129C57BL6DBA2Cdh1tm2KemCdh1Smad4tm21CxdSmad4tm21CxdTrp53tm1BrnTrp53tm1BrnTgVilcre20Syr0Smad4tm21CxdTrp53tm1BrnTgVilcre20SyrCdh1tm2KemCdh1

increased intestinal adenocarcinoma incidence_Cdh1<tm2Kem>/Cdh1<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Vil-cre)20Syr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• SMAD family member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:894293
• cadherin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88354
• transgene insertion 20, Sylvie Robine
  http://metadb.riken.jp/db/mgi_rdf/MGI:3053809
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdh1<tm2Kem>/Cdh1<+>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Vil-cre)20Syr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Smad4<tm2.1Cxd>|Trp53<tm1Brn>|Tg(Vil-cre)20Syr|Cdh1<tm2Kem>|Cdh1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased intestinal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0002957

文献

http://purl.org/net/cito/citesAsAuthority

• Jun Won. Park, et.al., Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis., Molecular cancer research : MCR, 2014, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/24784840