increased liver weight_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0,Tgfbr2<tm1Roes>/Tgfbr2<tm1Roes>

http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6DBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Tgfbr2tm1RoesTgfbr2tm1RoesTgAlbcre21MgnMob1bGtCC0690WtsiMob1atm11AsuzTgfbr2tm1Roes

increased liver weight_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0,Tgfbr2<tm1Roes>/Tgfbr2<tm1Roes>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transforming growth factor, beta receptor II
  http://metadb.riken.jp/db/mgi_rdf/MGI:98729
• MOB kinase activator 1A
  http://metadb.riken.jp/db/mgi_rdf/MGI:2442631
• transgene insertion 21, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176226
• MOB kinase activator 1B
  http://metadb.riken.jp/db/mgi_rdf/MGI:1915723

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0,Tgfbr2<tm1Roes>/Tgfbr2<tm1Roes>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Alb-cre)21Mgn|Mob1b<Gt(CC0690)Wtsi>|Mob1a<tm1.1Asuz>|Tgfbr2<tm1Roes>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * DBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased liver weight
  http://purl.obolibrary.org/obo/MP_0002981

文献

http://purl.org/net/cito/citesAsAuthority

• Miki. Nishio, et.al., Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice., Proceedings of the National Academy of Sciences of the United States of America, 2016, 113
  http://rdf.ncbi.nlm.nih.gov/pubmed/26699479