Miki. Nishio, et.al., Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice., Proceedings of the National Academy of Sciences of the United States of America, 2016, 113

http://rdf.ncbi.nlm.nih.gov/pubmed/26699479

Miki. Nishio, et.al., Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice., Proceedings of the National Academy of Sciences of the United States of America, 2016, 113

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Yap1<tm1c(KOMP)Mbp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5603606

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• liver fibrosis_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Yap1<tm1c(KOMP)Mbp>/Yap1<tm1c(KOMP)Mbp>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003333I129P2OlaHsdC57BL6C57BL6NDBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiYap1tm1cKOMPMbpYap1tm1cKOMPMbpTgAlbcre21Mgn0TgAlbcre21MgnYap1tm1cKOMPMbpMob1atm11AsuzMob1bGtCC0690Wtsi
• liver fibrosis_Ctgf<tm1.1Alea>/Ctgf<tm1.1Alea>,Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003333I129P2OlaHsd129S2SvPasC57BL6DBACtgftm11AleaCtgftm11AleaMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1bGtCC0690WtsiMob1atm11AsuzCtgftm11AleaTgAlbcre21Mgn
• increased liver weight_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Yap1<tm1c(KOMP)Mbp>/Yap1<tm1c(KOMP)Mbp>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6C57BL6NDBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiYap1tm1cKOMPMbpYap1tm1cKOMPMbpTgAlbcre21Mgn0TgAlbcre21MgnYap1tm1cKOMPMbpMob1atm11AsuzMob1bGtCC0690Wtsi
• abnormal bile duct physiology_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003252B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• abnormal cholangiocyte morphology_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0012236B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• liver fibrosis_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Wwtr1<tm1Hku>/Wwtr1<tm1Hku>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003333I129P2OlaHsdC57BL6DBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiWwtr1tm1HkuWwtr1tm1HkuTgAlbcre21Mgn0TgAlbcre21MgnMob1atm11AsuzWwtr1tm1HkuMob1bGtCC0690Wtsi
• abnormal cholangiocyte morphology_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Wwtr1<tm1Hku>/Wwtr1<tm1Hku>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0012236I129P2OlaHsdC57BL6DBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiWwtr1tm1HkuWwtr1tm1HkuTgAlbcre21Mgn0TgAlbcre21MgnMob1atm11AsuzWwtr1tm1HkuMob1bGtCC0690Wtsi
• increased hepatocyte proliferation_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003893B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• abnormal cholangiocyte morphology_Ctgf<tm1.1Alea>/Ctgf<tm1.1Alea>,Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0012236I129P2OlaHsd129S2SvPasC57BL6DBACtgftm11AleaCtgftm11AleaMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1bGtCC0690WtsiMob1atm11AsuzCtgftm11AleaTgAlbcre21Mgn
• jaundice_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000611B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• abdomen swellings_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0013119B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• increased liver weight_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Wwtr1<tm1Hku>/Wwtr1<tm1Hku>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6DBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiWwtr1tm1HkuWwtr1tm1HkuTgAlbcre21Mgn0TgAlbcre21MgnMob1atm11AsuzWwtr1tm1HkuMob1bGtCC0690Wtsi
• liver fibrosis_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003333B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• increased liver adenoma incidence_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003324B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• premature death_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002083B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• increased hepatobiliary system tumor incidence_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0010297B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• abnormal cholangiocyte morphology_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0,Tgfbr2<tm1Roes>/Tgfbr2<tm1Roes>
  http://metadb.riken.jp/0012236I129P2OlaHsdC57BL6DBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Tgfbr2tm1RoesTgfbr2tm1RoesTgAlbcre21MgnMob1bGtCC0690WtsiMob1atm11AsuzTgfbr2tm1Roes
• increased liver weight_Ctgf<tm1.1Alea>/Ctgf<tm1.1Alea>,Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002981I129P2OlaHsd129S2SvPasC57BL6DBACtgftm11AleaCtgftm11AleaMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1bGtCC0690WtsiMob1atm11AsuzCtgftm11AleaTgAlbcre21Mgn
• increased hepatocyte number_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0014038B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• increased hepatocellular carcinoma incidence_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003331B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• increased hepatobiliary system tumor incidence_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Alb<tm1(cre/ERT2)Mtz>/Alb<+>
  http://metadb.riken.jp/0010297I129P2OlaHsd129S2SvPasC57BL6Mob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiAlbtm1creERT2MtzAlbAlbAlbtm1creERT2MtzMob1bGtCC0690WtsiMob1atm11Asuz
• increased circulating bilirubin level_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005344B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• increased cholangiocarcinoma incidence_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0010315B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• liver fibrosis_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0,Tgfbr2<tm1Roes>/Tgfbr2<tm1Roes>
  http://metadb.riken.jp/0003333I129P2OlaHsdC57BL6DBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Tgfbr2tm1RoesTgfbr2tm1RoesTgAlbcre21MgnMob1bGtCC0690WtsiMob1atm11AsuzTgfbr2tm1Roes
• enlarged liver_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000599B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn
• abnormal cholangiocyte morphology_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Yap1<tm1c(KOMP)Mbp>/Yap1<tm1c(KOMP)Mbp>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0012236I129P2OlaHsdC57BL6C57BL6NDBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiYap1tm1cKOMPMbpYap1tm1cKOMPMbpTgAlbcre21Mgn0TgAlbcre21MgnYap1tm1cKOMPMbpMob1atm11AsuzMob1bGtCC0690Wtsi
• increased liver weight_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0,Tgfbr2<tm1Roes>/Tgfbr2<tm1Roes>
  http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6DBAMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Tgfbr2tm1RoesTgfbr2tm1RoesTgAlbcre21MgnMob1bGtCC0690WtsiMob1atm11AsuzTgfbr2tm1Roes
• postnatal lethality, incomplete penetrance_Mob1a<tm1.1Asuz>/Mob1a<tm1.1Asuz>,Mob1b<Gt(CC0690)Wtsi>/Mob1b<Gt(CC0690)Wtsi>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0011086B6CgMob1bGtCC0690WtsiMob1atm11AsuzTgAlbcre21MgnMob1atm11AsuzMob1atm11AsuzMob1bGtCC0690WtsiMob1bGtCC0690WtsiTgAlbcre21Mgn0Mob1atm11AsuzMob1bGtCC0690WtsiTgAlbcre21Mgn

class

http://purl.org/net/cito/citesAsAuthority

• Yap1<tm1c(KOMP)Mbp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5603606