abnormal long bone epiphyseal plate morphology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0

http://metadb.riken.jp/0003055I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor

abnormal long bone epiphyseal plate morphology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion, Andrzej Fertala
  http://metadb.riken.jp/db/mgi_rdf/MGI:5643752
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 1, Richard R Behringer
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176069

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe|Tg(Col2a1-cre)1Bhr|Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal long bone epiphyseal plate morphology
  http://purl.obolibrary.org/obo/MP_0003055

文献

http://purl.org/net/cito/citesAsAuthority

• Machiko. Arita, et.al., Mechanisms of aberrant organization of growth plates in conditional transgenic mouse model of spondyloepiphyseal dysplasia associated with the R992C substitution in collagen II., The American journal of pathology, 2015, 185
  http://rdf.ncbi.nlm.nih.gov/pubmed/25451152