Machiko. Arita, et.al., Mechanisms of aberrant organization of growth plates in conditional transgenic mouse model of spondyloepiphyseal dysplasia associated with the R992C substitution in collagen II., The American journal of pathology, 2015, 185

http://rdf.ncbi.nlm.nih.gov/pubmed/25451152

Machiko. Arita, et.al., Mechanisms of aberrant organization of growth plates in conditional transgenic mouse model of spondyloepiphyseal dysplasia associated with the R992C substitution in collagen II., The American journal of pathology, 2015, 185

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe
  http://metadb.riken.jp/db/mgi_rdf/MGI:5643753

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal chondrocyte physiology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0009780I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• abnormal chondrocyte morphology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0000166I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• decreased body length_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0001258I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• abnormal cranium size_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0010031I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• short femur_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0003109I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• increased diameter of tibia_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0008162I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• decreased body size_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• short tibia_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0002764I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• abnormal bone collagen fibril morphology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0011642I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• disorganized long bone epiphyseal plate_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0006397I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• abnormal primary cilium morphology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0013203I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• increased diameter of femur_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0008158I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• abnormal head size_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0011496I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• abnormal vertebrae morphology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0000137I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• decreased length of long bones_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0004686I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• abnormal long bone hypertrophic chondrocyte zone_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0000165I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor
• abnormal long bone epiphyseal plate morphology_Gt(ROSA)26Sor<tm5(ACTB-tTA)Luo>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
  http://metadb.riken.jp/0003055I129S1Sv129X1SvJC57BL6C57BL6JSJLGtROSA26Sortm5ACTBtTALuoGtROSA26SorTgCol2a1cre1Bhr0TgtetOCMVCol2a1R992CGFPAfe0TgtetOCMVCol2a1R992CGFPAfeTgCol2a1cre1BhrGtROSA26Sortm5ACTBtTALuoGtROSA26Sor

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe
  http://metadb.riken.jp/db/mgi_rdf/MGI:5643753