decreased insulin secretion_Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ins2-cre)25Mgn/0

http://metadb.riken.jp/0003059I129S4SvJaeC57BL6DBA2Insrtm1KhnInsrtm1KhnTgIns2cre25Mgn0Insrtm1KhnTgIns2cre25Mgn

decreased insulin secretion_Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ins2-cre)25Mgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• insulin receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:96575
• transgene insertion 25, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176225

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ins2-cre)25Mgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Insr<tm1Khn>|Tg(Ins2-cre)25Mgn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased insulin secretion
  http://purl.obolibrary.org/obo/MP_0003059

文献

http://purl.org/net/cito/citesAsAuthority

• Terumasa. Okada, et.al., Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance., Proceedings of the National Academy of Sciences of the United States of America, 2007, 104
  http://rdf.ncbi.nlm.nih.gov/pubmed/17416680